Protein-Lipid Interactions
From Membrane Domains to Cellular Networks
1. Auflage August 2005
XXVI, 444 Seiten, Hardcover
82 Abbildungen (24 Farbabbildungen)
3 Tabellen
Handbuch/Nachschlagewerk
Kurzbeschreibung
This first comprehensive handbook examines biophysical principles of membrane thermodynamics and structure, and goes on to discuss biochemical and cell biology processes, including mechanisms of membrane fusion and fission, pore-forming toxins and lipid rafts.
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure
Folding and Stability of Monomeric beta-Barrel Membrane Proteins
Principles, Kinetics and Stability of Bacteriorhodopsin Folding
Post-Integration Misassembly of Membrane Proteins and Disease
HOW PROTEINS SHAPE LIPIDS
A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins
Lipid and Detergent Interactions with Membrane Proteins Derived from Solution NMR
MEMBRANE PENETRATION BY TOXINS
Lipid Interactions of alpha-Helical Protein Toxins
Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins
Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides
MECHANISMS OF MEMBRANE FUSION
Cell Fusion in Development and Disease
Molecular Mechanisms of Intracellular Membrane Fusion
Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion
CHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTING
Protein-Lipid Interactions in the Formation of Raft Microdomains
Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes
TARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTION
In vitro and Cellular Membrane Binding Mechanisms of Membrane Targeting Domains
Structure and Interactions of C2 Domains at Membrane Surfaces
Structural Mechanisms of Allosteric Regulation by Membrane-binding domains
Umwelt & Gesundheit
"Insgesamt handelt es sich um eine rundum gelungene Zusammenstellung von Beiträgen über Lipid-Protein-Wechselwirkungen. Alle Beiträge verfügen über eine umfangreiche und aktuelle Literaturliste, besonders hervorzuheben ist auch, dass Daten aus Proteindatenbanken erhoben wurden, die eine gute Diskussionsgrundlage für weitere Arbeiten liefern. Für Forscher, die sich mit Lipid-Protein-Wechselwirkungen beschäftigen, ist das Buch auf jeden Fall eine Bereicherung."
Angewandte Chemie
Returning to Basel, he was appointed as a junior faculty member before joining thefaculty of the University of Virgina in 1990. He currently holds a chair in Molecular Physiology and Biological Physics and served as director of heinterdisciplinary program in biophysics at the University of Virginia from 1999-2003.