Copper-Oxygen Chemistry

Karlin, Kenneth D. / Itoh, Shinobu / Rokita, Steven (Herausgeber)

Wiley Series of Reactive Intermediates (Band Nr. 4)

1. Auflage Oktober 2011
480 Seiten, Hardcover
Fachbuch

ISBN: 978-0-470-52835-8

John Wiley & Sons

Kurzbeschreibung

This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology deals with the subject of oxidative processes mediated by copper ions within biological systems. The book addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond forming reactions as well as enantioselective oxidation chemistries. It covers a wide array of reaction types, such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing the O2 molecule, and progresses from biological systems and spectroscopy and related theory to bioinorganic models and applications.

Weitere Versionen

Preface to Series vii

Introduction ix

Contributors xi

1 Insights into the Proposed Copper-Oxygen Intermediates that Regulate the Mechanism of Reactions Catalyzed by Dopamine b-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, and Tyramine b-Monooxygenase 1
Robert L. Osborne and Judith P. Klinman

2 Copper Dioxygenases 23
Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier

3 Amine Oxidase and Galactose Oxidase 53
Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M. Dooley

4 Energy Conversion and Conservation by Cytochrome Oxidases 107
Angela Paulus and Simon de Vries

5 Multicopper Proteins 131
Takeshi Sakurai and Kunishige Kataoka

6 Structure and Reactivity of Copper-Oxygen Species Revealed by Competitive Oxygen-18 Isotope Effects 169
Justine P. Roth

7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes 197
Kazunari Yoshizawa

8 Chemical Reactivity of Copper Active-Oxygen Complexes 225
Shinobu Itoh

9 Cytochrome c Oxidase and Models 283
Zakaria Halime and Kenneth D. Karlin

10 Supramolecular Copper Dioxygen Chemistry 321
Jean-Noel Rebilly and Olivia Reinaud

11 Organic Synthetic Methods Using Copper Oxygen Chemistry 361
Marisa C. Kozlowski

Index 445

Kenneth D. Karlin is Ira Remsen Professor of Chemistry at Johns Hopkins University. His bioinorganic research focuses on coordination chemistry relevant to biological and environmental processes, involving copper or heme (porphyrin-iron) complexes. Dr. Karlin's main approach involves synthetic modeling, i.e., biomimetic chemistry. He is the winner of the prestigious F. Albert Cotton Award in Synthetic Inorganic Chemistry and the Sierra Nevada Distinguished Chemist Award, both awarded in 2009.

Shinobu Itoh focuses his current research on chemical modeling and application of novel active sites in biological systems. He was formerly an assistant professor at Osaka University, where he worked on the chemistry of coenzyme PQQ and cofactor TTQ as well as model compounds of galactose oxidase. In 1994, he was promoted to associate professor at Osaka University, where he collaborated with Professor Shunichi Fukuzumi in copper-dioxygen chemistry research. In 1999, he moved to Osaka City University as a full professor and started biological studies of dinuclear copper proteins, such as hemocyanin and tyrosinase. He returned to Osaka University in 2008 and further expanded his research interests to the design of artificial non-heme metalloenzymes using genetic engineering.

K. D. Karlin, Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA