Human Blood Plasma Proteins
Structure and Function
1. Auflage April 2008
538 Seiten, Hardcover
Monographie
Kurzbeschreibung
Human Blood Plasma Proteins provides an overview of human blood plasma proteins with special emphasis on their structure and function and, if known, also in relation to pathological states and diseases. The various systems in blood plasma like blood coagulation and fibrinolysis, the complement system, the immune defense system, the transport and storage systems, and many other systems with proteins as key players are discussed in detail. Special emphasis is placed on the structural/functional relationship of blood plasma proteins and the unique features of the many, mainly multidomain proteins in human blood plasma. Wherever possible, the authors establish links from the systematic understanding of blood proteins to the use of protein databases, to help the reader follow new developments and to make good use of the possibilities these databases offer.
Human plasma contains the most comprehensive version of the human proteome. The complexity of the 'plasma proteome' is quickly understood when one considers all the various forms of blood plasma proteins present in plasma: precursor and mature forms, splice variants, degradation products and of course all combinations of posttranslational modifications.
Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include:
* Introduction to blood components and blood plasma proteins
* Blood plasma protein domains, motifs and repeats
* Blood plasma protein families and posttranslational modifications
* Blood coagulation and fibrinolysis
* The complement system
* The immune system
* Enzymes
* Inhibitors
* Lipoproteins
* Hormones
* Cytokines and growth factors
* Transport and storage
The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.
Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
1 Introduction.
References.
Part I.
2 Blood Components.
References.
Data Sheet.
3 Blood Plasma Proteins.
References.
Part II.
4 Domains, Motifs and Repeats.
References.
5 Protein Families.
References.
6 Posttranslational Modifications.
References.
Part III.
7 Blood Coagulation and Fibrinolysis.
References.
Data Sheets.
8 The Complement System.
References.
Data Sheets.
9 The Immune System.
References.
Data Sheets.
10 Enzymes.
References.
Data Sheets.
11 Inhibitors.
References.
Data Sheets.
12 Lipoproteins.
References.
Data Sheets.
13 Hormones.
References.
Data Sheets.
14 Cytokines and Growth Factors.
References.
Data Sheets.
15 Transport and Storage.
References.
Data Sheets.
16 Additional Proteins.
Data Sheets.
Appendix.
Glossary.
Index.
