Pheochromocytoma

Pheochromocytoma is a rare neuroendocrine tumor with a highly
variable presentation. There is lack of agreement about the most
efficient and cost-effective methods for diagnosis and localization
of the tumor, which can be lethal if not identified and treated
promptly.Autopsy studies indicate that up to 50% of all cases
remain undiagnosed until death.



Between 30 and 35% of the tumors have a hereditary basis.
Development of malignancy is highly variable -- from less than 5%
to more than 50% depending on the mutation; there is currently no
effective cure.

This volume encompasses a number of themes in several sections:
genetics and clinical decision-making; genetics, molecular pathways
of tumorigenesis, and divergent phenotypes; kaleidoscopic
presentations and a minefield for differential diagnosis of
pheochromocytoma; biochemical diagnosis: can we reach consensus?;
tumor localization and the evolving importance of functional
imaging; and new molecular markers and targets for diagnosis and
treatment of malignant pheochromcytoma.

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