Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function

Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are
vital to many cellular functions and physiological processes. This
volume, which is the proceedings of the fifth in a series of
international conferences, includes contributions that merge
molecular biology, biochemistry, biophysics, and physiology,
providing novel insights that significantly advance our
understanding of Na+/Ca2+ exchanger in areas ranging from molecular
mechanisms to the involvement in human disease.



Several important themes are addressed: (1) structure-function
relationships of the exchanger; (2) regulation of the exchanger;
(3) Na/Ca exchanger gene regulation; (4) cellular location and
targeting of the exchanger; (5) NC(K)X and PMCA KO mice; (6) Na/Ca
exchanger interactions with other proteins; (7) Na/Ca exchange in
cardiac function; (8) Na/Ca exchange in neuronal function; (9)
Ca2+-extruding mechanisms and apoptosis; (10) Na/Ca exchange in
smooth muscle, kidney, and endocrine function; (11) Na/Ca exchange
inhibitors: therapeutic opportunities. Experts in the field of the
plasma membrane Ca2+-ATPase (PMCA) have also contributed.

The rate of progress in this field has been rapidly increasing,
and new concepts have emerged regarding the relation between
molecular structure and physiological function. New ideas on
physiological modes of regulation have been increasingly testable
through the use of transgenic animal models.

This volume and the conference that preceded it continue the
tradition of sharing information to fuel new advances in this
exciting and important area of research.

NOTE: Annals volumes are available for sale as individual
books or as a journal. For information on institutional journal
subscriptions, please visit href="http://www.blackwellpublishing.com/nyas">www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of
Sciences directly to place your order (href="http://www.nyas.org/">www.nyas.org). Members of the New
York Academy of Science receive full-text access to the Annals
online and discounts on print volumes. Please visit href="http://www.nyas.org/MemberCenter/Join.aspx">http://www.nyas.org/MemberCenter/Join.aspx
for more information about becoming a member