Handbook of Dermatology
A Practical Manual
2. Auflage November 2019
416 Seiten, Softcover
Praktikerbuch
ISBN:
978-1-118-40854-4
John Wiley & Sons
Weitere Versionen
The Handbook of Dermatology consolidates the essential information required for best-practice patient care into one pocket-sized volume. This indispensable reference guide enables practicing and prospective dermatologists to easily look up information on a wide range of dermatological diseases and quickly access the algorithms, protocols, guidelines, and staging and scoring systems that are vital to both clinical practice and exam success. Written and edited by former residents and attending physicians, the Handbook contains up-to-date information on general dermatology, surgery, and therapeutics.
Preface xv
Acknowledgments xvii
Part 1 General Dermatology 1
Common Work-Ups, Signs, and Management 3
Dermatologic Differential Algorithm 3
Direct Immunofluorescence (Dif) 3
False positive/negative DIFs 3
Workup Quick Reference Orders 4
Acne 6
Alopecia Workup 7
Telogen effluvium 10
Androgenic alopecia 10
Alopecia areata 11
Other alopecia treatments 12
Aphthosis Workup and Treatment 13
Dermatologic Signs 15
Folliculitis 21
Melasma 22
Immunology and Immunologic Disease 24
Lupus Erythematosus 24
Autoantibody 26
Sensitivities and specificities 26
In connective tissue diseases 28
Anti-nuclear antibodies 29
ANCA (Anti-neutrophil cytoplasmic antibodies) 30
Treatment of ANCA-associated vasculitis 30
Vasculitis 31
Small vessel vasculitis 31
Medium vessel vasculitis 33
Large vessel vasculitis 34
Cryoglobulinemia 34
Bullous Disorders 36
Intracorneal/subcorneal 36
Intraepidermal 36
Suprabasilar 37
Subepidermal with little inflammation 37
Epidermolysis bullosa 39
Major bullous diseases - clinicopathologic findings 42
Complement 46
Angioedema and complement levels 46
Complement deficiencies 47
GVHD 47
HLA associations 48
Th profiles 50
Special Sites: Glands, Nail, Bone, Mucosa 51
Glands 51
Nail terminology 53
Disorders or drugs associated with nail, Bone, or ocular findings 57
Genital ulcers 67
Infection and Infestations 68
Fungal Disease / Mycoses 68
Laboratory tests 68
Superficial mycoses 68
Cutaneous mycoses 69
Subcutaneous mycoses 71
Systemic mycoses 73
Opportunistic mycoses 75
Viruses and diseases 78
Human papilloma virus 79
Other viral diseases 80
Infections/Bugs 83
Vector-borne diseases 83
Creatures in dermatology 88
Contact and Plant Dermatitis 93
Patch testing 93
Common contact allergens 95
Allergic vs. irritant contact dermatitis 104
Allergens - location specific 105
Features suggestive of specific irritant/toxin 106
Plants and Dermatoses 106
Tumors and Infiltrates 109
Cutaneous T Cell Lyphoma 109
Cutaneous B-cell lymphoma 113
Leukemia cutis 113
Monoclonal Gammopathies in Dermatology 114
Tumors and gene associations 115
For Melanoma, BCC, and SCC, see Skin Cancer 221
Systemic and Metabolic Diseases 117
Amyloidoses 117
Histiocytosis 119
Xanthomas 124
Hyperlipoproteinemias 125
Vitamin Deficiencies/Hypervitaminoses 127
Pediatric and Pregnancy Dermatology 131
Vascular tumors and malformation 131
Infantile Hemangioma (IH) Management 132
Neonatal vesiculopustular eruptions 137
Genodermatoses 142
Chromosome abnormalities 171
Disorders of cornification 171
Disorders of connective tissue 175
Ehlers-Danlos 177
Collagen types 178
Disorder of hair, Nail, ectoderm 179
Tumor syndromes 185
Disorders of vascularization 186
Disorders of metabolism 189
Porphyrias 191
Disorders of pigmentation 193
Immunodeficiency syndromes 196
Miscellaneous 198
Dermatoses of pregnancy 200
Dermoscopy and Dermatopathology 202
Dermoscopy 202
Dermatopathology 206
Histochemical staining 206
Immunohistochemical staining 207
Pathologic bodies 210
Cysts 214
Other derm path buzzwords, Patterns, DDx 215
Part 2 Surgical and Cosmetic Dermatology 219
Surgical Dermatology 221
Skin cancer 221
Surgical margin guidelines 221
Indication for Mohs micrographic surgery 222
Melanoma 223
Squamous cell carcinoma (SCC) 228
Prophylactic antibiotics and antivirals 230
Guideline for Prophylactic antibiotics 230
Algorithm for antibiotic prophylaxis 231
Guideline for prophylactic antivirals 231
Antiseptic scrubs 232
Anesthetics 234
Dose calculation 234
Standard formula for buffered Lidocaine 234
Tumescent anesthesia 234
Topical anesthetic (see drug section pg. 316) 235
Adverse reaction to local anesthetics 235
Local anesthetic 236
Nerve blocks 237
Surgical anatomy 237
Anatomy of the face 237
Danger zones in surgery 242
Dermatomal distribution of sensory nerves 244
Anatomy of the lower extremity venous system 245
Anatomy of the nail 246
Cutaneous reconstruction 247
Undermining depths in reconstruction 248
Reconstruction algorithm: STAIRS 248
Sutures 260
Absorbable 260
Nonabsorbable 261
Suture removal time 262
Electrosurgery 262
Wound healing 262
Wound dressing 263
Cosmetic Dermatology 264
Laser 264
Laser fundamentals 264
Laser treatment of tattoo pigment 266
Photoinduced eye injury 267
Laser wavelength depth of penetration and the electromagnetic spectrum 268
Absorption spectra of major skin chromophores 268
Photodynamic therapy 269
Photosensitizer properties and options 269
PDT Protocol 270
UV spectrum 271
UV spectrum and wavelengths 271
UVB protection vs SPF 272
UV protection measurements 272
UV associations/specificities 273
Glogau wrinkle scale 273
Fitzpatrick skin type 274
Chemical peels 274
Pre-peel consideration 274
Peeling agents 275
Botulinum toxin 277
Injectable for adipolysis 280
Fillers 281
Protocol for vascular occlusion from fillers 288
Venous disease treatment 288
Vein treatment algorithm 288
Sclerotherapy 289
Preparing dilution of sclerosants 290
CEAP classification for venous disease 292
Venous clinical severity score 292
Part 3 Drugs and Therapies 293
Medication Quick Reference 295
Topical steroids classified by strength 295
Nonsteroidals 297
Commonly used drugs in dermatology 297
Systemic Medications 302
Antimalarials 302
Immunosuppressive agents 303
Systemic retinoids 306
Biologics 307
General Reference 310
Metric measurements 310
Dose calculations 310
Topical medication dispensing and absorption 310
Corticosteroid Dosage Equivalence 311
Acne - Topical 311
Antibiotics/antimicrobial 311
Keratolytics 312
Retinoids 313
Others 313
Acne - Oral 314
Antibiotics 314
Retinoids 315
Others 315
Analgesics 315
Anesthetics - topical (see also topical anesthetic pg. 235) 316
Anesthetics - topical compounded 316
Antibiotics 316
Topical/antiseptic 316
Systemic 317
Preoperative prophylaxis see pg. 230
Postoperative skin infection 319
Sensitivity 321
Regimens 322
STDs 323
Antifungals 324
Topical 324
Oral 325
Antifungal regimens 327
Candidal infection 327
Pityrosporum folliculitis 327
Onychomycosis 327
Tinea versicolor (Malassezia) 328
Tinea capitis 328
Tinea corporis 328
Tinea pedis 329
Antiparasitics 330
Scabies 330
Lice 330
Antivirals 331
HSV 331
Herpes zoster/VZV 333
Genital warts 333
Verruca vulgaris 334
Molluscum 334
Antihistamines 334
Sedating 335
Nonsedating 335
H2-blockers 335
Antipruritic 336
Topical 336
Oral 336
Anxiolytics/Sedation 338
Benzodiazepines 338
Antihistamines 339
Bleaching Agents/Depigmenting Agents 340
Hair 341
Alopecia - androgenic 341
Alopecia - areata 341
Hypertrichosis 342
Hypotrichosis - eyelash 342
Hyperhidrosis 342
Psoriasis 343
Topical agents 343
Tar 343
Anthralin/dithranol 343
Systemic agents 343 (see also Systemic Medications pg. 306)
Rosacea 344
Antibiotics/antimicrobial - topical 344
Keratolytics 344
Vasoconstrictor 344
Other 344
Antibiotics - systemic 344
Seborrheic Dermatitis 345
Skin Cancer - Topical and Oral Chemotherapy 345
Actinic keratoses (AK) 345
Basal cell carcinoma (BCC) 346
CTCL 346
Melanoma 347
Vasoactive/Antiplatelet Agents 347
Vitamins/Nutritional Supplements 348
Wound Care 348
Miscellaneous Meds 348
Cytochrome P-450 interactions 349
Pregnancy Categories of Commonly Used Dermatologic Agents 350
Common Dermatologic Drugs and Teratogenic Effects 351
Dermatologic Drugs Reportedly Associated with Contraceptive Failure 352
Drug Eruptions 352
Chemotherapeutic Agents and Skin Changes 355
Antidote to extravasation of chemotherapeutic agents 358
UV Light Treatment 359
UVA/UVB dosing 359
NBUVB dosing 359
PUVA 359
Toxic Epidermal Necrolysis (TEN) Protocol 361
Diagnosis of TEN 361
Triage algorithm for TEN patients 362
Treatment for all TEN patients 363
Appendix I American Burn Assocation Burn Center Referral Criteria 364
Appendix SCORTEN Score 365
Appendix III IVIg 365
Appendix IV Further Reading for TEN/SJS 366
Index 367
Color plate section can be found facing page 208
Acknowledgments xvii
Part 1 General Dermatology 1
Common Work-Ups, Signs, and Management 3
Dermatologic Differential Algorithm 3
Direct Immunofluorescence (Dif) 3
False positive/negative DIFs 3
Workup Quick Reference Orders 4
Acne 6
Alopecia Workup 7
Telogen effluvium 10
Androgenic alopecia 10
Alopecia areata 11
Other alopecia treatments 12
Aphthosis Workup and Treatment 13
Dermatologic Signs 15
Folliculitis 21
Melasma 22
Immunology and Immunologic Disease 24
Lupus Erythematosus 24
Autoantibody 26
Sensitivities and specificities 26
In connective tissue diseases 28
Anti-nuclear antibodies 29
ANCA (Anti-neutrophil cytoplasmic antibodies) 30
Treatment of ANCA-associated vasculitis 30
Vasculitis 31
Small vessel vasculitis 31
Medium vessel vasculitis 33
Large vessel vasculitis 34
Cryoglobulinemia 34
Bullous Disorders 36
Intracorneal/subcorneal 36
Intraepidermal 36
Suprabasilar 37
Subepidermal with little inflammation 37
Epidermolysis bullosa 39
Major bullous diseases - clinicopathologic findings 42
Complement 46
Angioedema and complement levels 46
Complement deficiencies 47
GVHD 47
HLA associations 48
Th profiles 50
Special Sites: Glands, Nail, Bone, Mucosa 51
Glands 51
Nail terminology 53
Disorders or drugs associated with nail, Bone, or ocular findings 57
Genital ulcers 67
Infection and Infestations 68
Fungal Disease / Mycoses 68
Laboratory tests 68
Superficial mycoses 68
Cutaneous mycoses 69
Subcutaneous mycoses 71
Systemic mycoses 73
Opportunistic mycoses 75
Viruses and diseases 78
Human papilloma virus 79
Other viral diseases 80
Infections/Bugs 83
Vector-borne diseases 83
Creatures in dermatology 88
Contact and Plant Dermatitis 93
Patch testing 93
Common contact allergens 95
Allergic vs. irritant contact dermatitis 104
Allergens - location specific 105
Features suggestive of specific irritant/toxin 106
Plants and Dermatoses 106
Tumors and Infiltrates 109
Cutaneous T Cell Lyphoma 109
Cutaneous B-cell lymphoma 113
Leukemia cutis 113
Monoclonal Gammopathies in Dermatology 114
Tumors and gene associations 115
For Melanoma, BCC, and SCC, see Skin Cancer 221
Systemic and Metabolic Diseases 117
Amyloidoses 117
Histiocytosis 119
Xanthomas 124
Hyperlipoproteinemias 125
Vitamin Deficiencies/Hypervitaminoses 127
Pediatric and Pregnancy Dermatology 131
Vascular tumors and malformation 131
Infantile Hemangioma (IH) Management 132
Neonatal vesiculopustular eruptions 137
Genodermatoses 142
Chromosome abnormalities 171
Disorders of cornification 171
Disorders of connective tissue 175
Ehlers-Danlos 177
Collagen types 178
Disorder of hair, Nail, ectoderm 179
Tumor syndromes 185
Disorders of vascularization 186
Disorders of metabolism 189
Porphyrias 191
Disorders of pigmentation 193
Immunodeficiency syndromes 196
Miscellaneous 198
Dermatoses of pregnancy 200
Dermoscopy and Dermatopathology 202
Dermoscopy 202
Dermatopathology 206
Histochemical staining 206
Immunohistochemical staining 207
Pathologic bodies 210
Cysts 214
Other derm path buzzwords, Patterns, DDx 215
Part 2 Surgical and Cosmetic Dermatology 219
Surgical Dermatology 221
Skin cancer 221
Surgical margin guidelines 221
Indication for Mohs micrographic surgery 222
Melanoma 223
Squamous cell carcinoma (SCC) 228
Prophylactic antibiotics and antivirals 230
Guideline for Prophylactic antibiotics 230
Algorithm for antibiotic prophylaxis 231
Guideline for prophylactic antivirals 231
Antiseptic scrubs 232
Anesthetics 234
Dose calculation 234
Standard formula for buffered Lidocaine 234
Tumescent anesthesia 234
Topical anesthetic (see drug section pg. 316) 235
Adverse reaction to local anesthetics 235
Local anesthetic 236
Nerve blocks 237
Surgical anatomy 237
Anatomy of the face 237
Danger zones in surgery 242
Dermatomal distribution of sensory nerves 244
Anatomy of the lower extremity venous system 245
Anatomy of the nail 246
Cutaneous reconstruction 247
Undermining depths in reconstruction 248
Reconstruction algorithm: STAIRS 248
Sutures 260
Absorbable 260
Nonabsorbable 261
Suture removal time 262
Electrosurgery 262
Wound healing 262
Wound dressing 263
Cosmetic Dermatology 264
Laser 264
Laser fundamentals 264
Laser treatment of tattoo pigment 266
Photoinduced eye injury 267
Laser wavelength depth of penetration and the electromagnetic spectrum 268
Absorption spectra of major skin chromophores 268
Photodynamic therapy 269
Photosensitizer properties and options 269
PDT Protocol 270
UV spectrum 271
UV spectrum and wavelengths 271
UVB protection vs SPF 272
UV protection measurements 272
UV associations/specificities 273
Glogau wrinkle scale 273
Fitzpatrick skin type 274
Chemical peels 274
Pre-peel consideration 274
Peeling agents 275
Botulinum toxin 277
Injectable for adipolysis 280
Fillers 281
Protocol for vascular occlusion from fillers 288
Venous disease treatment 288
Vein treatment algorithm 288
Sclerotherapy 289
Preparing dilution of sclerosants 290
CEAP classification for venous disease 292
Venous clinical severity score 292
Part 3 Drugs and Therapies 293
Medication Quick Reference 295
Topical steroids classified by strength 295
Nonsteroidals 297
Commonly used drugs in dermatology 297
Systemic Medications 302
Antimalarials 302
Immunosuppressive agents 303
Systemic retinoids 306
Biologics 307
General Reference 310
Metric measurements 310
Dose calculations 310
Topical medication dispensing and absorption 310
Corticosteroid Dosage Equivalence 311
Acne - Topical 311
Antibiotics/antimicrobial 311
Keratolytics 312
Retinoids 313
Others 313
Acne - Oral 314
Antibiotics 314
Retinoids 315
Others 315
Analgesics 315
Anesthetics - topical (see also topical anesthetic pg. 235) 316
Anesthetics - topical compounded 316
Antibiotics 316
Topical/antiseptic 316
Systemic 317
Preoperative prophylaxis see pg. 230
Postoperative skin infection 319
Sensitivity 321
Regimens 322
STDs 323
Antifungals 324
Topical 324
Oral 325
Antifungal regimens 327
Candidal infection 327
Pityrosporum folliculitis 327
Onychomycosis 327
Tinea versicolor (Malassezia) 328
Tinea capitis 328
Tinea corporis 328
Tinea pedis 329
Antiparasitics 330
Scabies 330
Lice 330
Antivirals 331
HSV 331
Herpes zoster/VZV 333
Genital warts 333
Verruca vulgaris 334
Molluscum 334
Antihistamines 334
Sedating 335
Nonsedating 335
H2-blockers 335
Antipruritic 336
Topical 336
Oral 336
Anxiolytics/Sedation 338
Benzodiazepines 338
Antihistamines 339
Bleaching Agents/Depigmenting Agents 340
Hair 341
Alopecia - androgenic 341
Alopecia - areata 341
Hypertrichosis 342
Hypotrichosis - eyelash 342
Hyperhidrosis 342
Psoriasis 343
Topical agents 343
Tar 343
Anthralin/dithranol 343
Systemic agents 343 (see also Systemic Medications pg. 306)
Rosacea 344
Antibiotics/antimicrobial - topical 344
Keratolytics 344
Vasoconstrictor 344
Other 344
Antibiotics - systemic 344
Seborrheic Dermatitis 345
Skin Cancer - Topical and Oral Chemotherapy 345
Actinic keratoses (AK) 345
Basal cell carcinoma (BCC) 346
CTCL 346
Melanoma 347
Vasoactive/Antiplatelet Agents 347
Vitamins/Nutritional Supplements 348
Wound Care 348
Miscellaneous Meds 348
Cytochrome P-450 interactions 349
Pregnancy Categories of Commonly Used Dermatologic Agents 350
Common Dermatologic Drugs and Teratogenic Effects 351
Dermatologic Drugs Reportedly Associated with Contraceptive Failure 352
Drug Eruptions 352
Chemotherapeutic Agents and Skin Changes 355
Antidote to extravasation of chemotherapeutic agents 358
UV Light Treatment 359
UVA/UVB dosing 359
NBUVB dosing 359
PUVA 359
Toxic Epidermal Necrolysis (TEN) Protocol 361
Diagnosis of TEN 361
Triage algorithm for TEN patients 362
Treatment for all TEN patients 363
Appendix I American Burn Assocation Burn Center Referral Criteria 364
Appendix SCORTEN Score 365
Appendix III IVIg 365
Appendix IV Further Reading for TEN/SJS 366
Index 367
Color plate section can be found facing page 208
Margaret W. Mann is Associate Professor and Director of Aesthetic Dermatology, University Hospitals, Case Western School of Medicine, Cleveland, OH, USA. She is the Co-Founder of Innova Dermatology, Hendersonville, TN, USA.
Daniel L. Popkin is Assistant Chief of Dermatology, Louis Stokes VA Medical Center and Assistant Professor of Dermatology, University Hospitals, Case Western School of Medicine, Cleveland, OH, USA. He is the Co-Founder of Innova Dermatology, Hendersonville, TN, USA.
Daniel L. Popkin is Assistant Chief of Dermatology, Louis Stokes VA Medical Center and Assistant Professor of Dermatology, University Hospitals, Case Western School of Medicine, Cleveland, OH, USA. He is the Co-Founder of Innova Dermatology, Hendersonville, TN, USA.
