New Drug Development for Known and Emerging Viruses
Methods and Principles in Medicinal Chemistry
1. Auflage April 2021
448 Seiten, Hardcover
Discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets and viral disease mechanisms. Includes an outlook on emerging pathogens such as Ebola, West Nile, Norovirus and Coronavirus.
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Discusses how to address the need for fighting Ebola, SARS Corona, and other human viruses by building on the successes in antiviral therapy of the past decades
Written by leading medicinal chemists and virologists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antivarl drugs, targets and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronovirus-2 causing the current pandemic.
'New Drug Development for Known and Emerging Viruses' describes the discovery and development process for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses.
* Covers the entire field of antiviral drug discovery and development
* Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2
* Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle
* Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues
'New Drug Development for Known and Emerging Viruses' is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.
Curing Hepatitis C with Direct-Acting Antiviral Therapy
Antiviral Drugs against Influenza Virus
Respiratory Syncytial Virus Immunoreactivity, Vaccine development, and Therapeutics
Herpes simplex viruses
Antiviral strategies against the Human Cytomegalo Virus: Inhibitors of Viral Terminase
Antiviral targeting of the complex Epstein Barr virus life cycle
Kaposi's Sarcoma-associated Herpesvirus - antiviral treatment
Hepatitis B virus: HBV capsid assembly modulators (CAMs)
Hepatitis E virus - Current development in antiviral strategies
Antiviral Therapy of Adenovirus Infections
New Developments in Antiviral Drugs against ssDNA-Viruses: Human Parvovirus Infection
Antiviral targets and strategies to treat and prevent human norovirus infections
Antiviral strategies against (non-polio) picornaviruses
Novel antiviral strategies against emerging arbovirus infections
Current Therapies for Biosafety Level 4 Pathogens
Severe Acute Respiratory Syndrome (SARS) Coronavirus (SARS-CoVs) 1 and 2
Helmut Buschmann, PhD, has over 25 years of international experience in drug discovery research and drug development in the pharmaceutical/biotechnology sectors in different therapeutic areas, from pain research to anti-infectives. Currently, he is Head of Chemistry, Pharmaceutical Development and Patent Affairs at AiCuris and cofounder and co-owner of RD&C Research, Development & Consulting in Vienna.