Integrated Molecular Medicine for Neuronal and Neoplastic Disorders, Volume 1086
Annals of the New York Academy of Sciences
1. Auflage Januar 2007
200 Seiten, Softcover
Wiley & Sons Ltd
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Neurodegenerative disorders and malignant tumors are usually
resistant to any treatment, and the mortality rate is very high for
persons with these conditions. Accordingly, finding effective
treatments for these diseases is one of the most serious issues for
medicine in the 21st century.
In this volume, the molecular mechanisms of neurodegenerative
disorders and malignant tumors are addressed, as are new
therapeutic tools that exploit our understanding of these disease
mechanisms. Substantial evidence for the existence of common
molecular pathways for both neurodegeneration and tumor growth has
been found, and many novel molecules related to both of them have
also been discovered.
Because integrated research on neuronal and neoplastic disorders
is singularly effective in overcoming these disorders, this volume
will be an excellent source of information on the state of the
research in this field and on the development of its applications
in human disease therapy.
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Preface: Integrated Molecular Medicine for Neuronal andNeoplastic Disorders.
Part I: Motor Neuron Diseases:.
1. Gene Expression Profiling Toward Understanding of ALSPathogenesis: Fumiaki Tanaka, Jun-ichi Niwa, Shinsuke Ishigaki,Masahiko Yamamoto, Masahisa Katsuno, Manabu Doyu and Gen Sobue.
2. Untitled: Mimoun Azzouz.
3. Role of Polyunsaturated Fatty Acids for Misfolding ProteinAggregations; Implication for Neurodegenerative Diseases:Yeon-Jeong Kim and Ryosuke Takahashi.
4. Alleviating Neurodegeneration by an Anti-Cancer Agent -an Hsp90 Inhibitor (17-AAG): Masahiro Waza, Hiroaki Adachi,Masahisa Katsuno, Makoto Minamiyama,.
Fumiaki Tanaka, and Gen Sobue.
Part II: Alzheimer's Disease and Related NeurodegenerativeDisorders:.
5. LRP in Amyloid-b Production and Metabolism: Guojun Bu, JudyCam, and Celina Zerbinatti.
6. Neuronal Differentiation is Accompanied by Increased Levelsof SNAP-25 Protein in Fetal Rat Primary Cortical Neurons-Implications in Neuronal Plasticity and Alzheimer's Disease: JasonA Bailey and Debomoy K. Lahiri.
7. Myosin Va Mutation in Rats is an Animal Model for the HumanHereditary Neurological Disease, Griscelli Syndrome Type 1: YoshikoTakagishi and Yoshiharu Murata.
Part III: Neuroprotective Strategy for NeurodegenerativeDiseases:.
8. Brain Keratan Sulfate and Glial Scar Formation: HaoqianZhang, Kenji Uchimura and Kenji Kadomatsu.
9. The Direct and Indirect Effects of Serofendic Acid onNeuroprotection: Yukiko Doi, Jianfeng Liang, Reiko Kuno, GuiqinZang, Jun Kawanokuchi, Izumi Yawata, Hideyuki Takeuchi, TetsuyaMizuno, and Akio Suzumura.
10. Cytoplasmic Lipid Droplets: Re-discovery of an Old Structureas a Unique Platform: Toyoshi Fujimoto and Yuki Ohsaki.
Part IV: Neuronal Polarity and PsychiatricDisorders:.
11. Molecular mechanisms of Axon Specification and NeuronalDisorders: Takeshi Yoshimura, Nariko Arimura, and KozoKaibuchi.
12. Untitled: Naoya Sawamura, Akira Sawa et al.
13. Psychological, Neuroimaging and Biochemical Studies onFunctional Association between Impulsive Behavior and the 5-HT2AReceptor Gene Polymorphism in Humans: Michio Nomura and YasuyukiNomura.
14. Investigating Gene-to-Behavior Pathways in PsychiatricDisorders: The Use of a Comprehensive Behavioral Test Battery onGenetically Engineered Mice: Keizo Takao and Tsuyoshi Miyakawa.
15. Animal Model of Schizophrenia: Dysfunction of NMDAReceptor-Signaling in Mice following Withdrawal from RepeatedAdministration of Phencyclidine: Toshitaka Nabeshima, AkihiroMouri, Rina Murai, Yukihiro Noda.
Part V: Novel Targets for Cancer Therapy:.
16. Girdin, a Novel Actin-Binding Protein, and its Family ofProteins Possess Versatile functions in the AKT and WNT SignalingPathways: Atsushi Enomoto, Jiang Ping, and Masahide Takahashi.
17. Biosignals Modulated by Tumor-associated CarbohydrateAntigens: Novel Targets for Cancer Therapy: Koichi Furukawa,Kazunori Hamamura, Aixinjueluo Wei, Keiko Furukawa.
18: Untitled: Naing Naing Mon, Michinari Hamaguchi et al.
19. SFK-STAT Pathway: An Alternative and Important Way toMalignancies: Fumihiko Hayakawa and Tomoki Naoe.
20. Pharmacogenetic Approach for Cancer Treatment-TailoredMedicine in Practice: Yoshinori Hasegawa, Yuichi Ando, Maki Ando,Naozumi Hashimoto, Kazuyoshi Imaizumi, and Kaoru Shimokata.
21. Involvement of DPPIV/CD26 in Epithelial Morphology andSuppressed Invasive Ability in Ovarian Carcinoma Cells: HiroakiKajiyama, Kiyosumi Shibata, Mikio Terauchi, Kazuhiko Ino, AkihiroNawa, and Fumitaka Kikkawa