Handbook of Chemical Glycosylation

Advances in Stereoselectivity and Therapeutic Relevance

Demchenko, Alexei V. (Herausgeber)

1. Auflage Februar 2008
XXII, 502 Seiten, Hardcover
492 Abbildungen
14 Tabellen
Handbuch/Nachschlagewerk

ISBN: 978-3-527-31780-6

Wiley-VCH, Weinheim

Kurzbeschreibung

Für jedes Kapitel dieses Werkes zeichnen hochkarätige Wissenschaftler verantwortlich, die selbst in der Carbohydrat-Forschung tätig sind. Die am weitesten verbreiteten Methoden zur Konstruktion von O-glykosidischen Bindungen bilden einen Schwerpunkt der Darstellung.

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Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.

GENERAL ASPECTS OF THE GLYCOSIDIC BOND FORMATION
GLYCOSIDE SYNTHESIS FROM ANOMERIC HALIDES
Glycosyl Fluorides
Glycosyl Chlorides, Bromides, and Iodides
GLYCOSIDE SYNTHESIS FROM 1-OXYGEN-SUBSTITUTED GLYCOSYL DONORS
Hemiacetals and O-Acyl/Carbonyl Derivatives
Glycosyl Imidates
Anomeric Transglycosylation
Phosphites, Phosphates, and Other O--P Derivatives
GLYCOSIDE SYNTHESIS FROM 1-SULFUR/SELENIUM-SUBSTITUTED DERIVATIVES
Thioalkyl and Thioaryl Glycosides
Sulfoxides, Sulfimides, and Sulfones
Xanthates, Thioimidates, and Other Thio Derivatives
Selenoglycosides
OTHER METHODS FOR GLYCOSIDE SYNTHESIS
Orthoesters and Related Derivatives
Dehydro and Anhydro Derivatives
Miscellaneous Glycosyl Donors
Indirect and Special Methods

Born in 1965, Alexei Demchenko gained his MSc in chemical engineering from Mendeleev University of Chemical Technology, Russia, in 1988, before joining the Zelinski Institute of Organic Chemistry, at the Russian Academy of Sciences, Moscow. It was here, under Professor Kochetkov, that he took his first steps in researching carbohydrate synthesis. In 1993 he was awarded a PhD for his work on the development of thiocyanate methodology for stereospecific glycosylation and, after two post-doctoral years under Kochetkov, he joined Geert-Jan Boons' group at the University of Birmingham, UK, as a BBSRC post-doctoral research fellow. In 1998 he moved with Professor Boons to the Complex Carbohydrate Research Center at the University of Georgia as a research associate, where his research focused on the synthesis of complex oligosaccharides for immunological studies and the exploration of chemical O-sialylation. In 2001 he joined the University of Missouri St. Louis as an assistant professor of chemistry and biochemistry. Professor Demchenko is a recipient of the CAREER award from the National Science Foundation, and has co-authored over 50 articles, reviews, and book chapters. His current research interests are in the field of synthetic carbohydrate chemistry.

A. V. Demchenko, University of Missouri, USA