The Way of Synthesis

INTRODUCTION
The History of Synthesis
Milestones in Structure Elucidation
Milestones in Organic Synthesis

STRATEGY AND TACTICS
Principles and Issues Impacting Synthesis (Strategy)
Principles and Issues Impacting Design - Dimensional Analysis (Strategy)
Principles and Issues of Methods (Tactics)

COMPARATIVE DESIGN: CLASSICS IN TERPENE SYNTHESIS
Juvenile Hormones
Cedrenes
Zizaanes
Hydroazulenes
Vernolepin
Triquinanes
Compactin
Aphidicolin
Miscellaneous Diterpenes
Taxol

COMPARATIVE DESIGN: CLASSICS IN ALKALOID SYNTHESIS
Introduction
Lycopodium Alkaloids
Daphniphyllum Alkaloids, Daphnilactone A
Pyrrolizidine Alkaloids
Amaryllidaceae Alkaloids
Morphine
Indole Alkaloids

MISCELLANEOUS SYNTHESES
Maytansine and Other Macrocyclic Natural Products
Palytoxin
Brevetoxins and Other Linear Polycyclic Ethers
Indinavir
OUTLOOK

"Hudlicky hat ein sehr persönliches Buch geschaffen, das sich an einigen Stellen spannend liest. Im
Gegenzug zu Nicolaous "Classics in Total Synthesis" mit detaillierten Abhandlungen einiger Zwischenschritte wird in "The Way of Synthesis: Evolution of Design and Methods for Natural Products" eine eher gesamtheitliche Betrachtung gegeben, die auch vor philosophischen Fragestellungen nicht halt macht. Fortgeschrittene Studenten, die sich fragen, auf welchem Arbeitsgebiet sie promovieren wollen, werden genauso eine Antwort finden, wie Personen, welche sich für Taktiken und Strategien in der Totalsynthese interessieren."
http://www.organische-chemie.ch/Buch/352731444X.htm
Nov. 07

"Das Buch kann allen akademischen Wissenschaftlern im Bereich der organischen Chemie empfohlen werden, die Interesse an historischen Aspekten der Totalsynthese haben,"
Angewandte Chemie
2008/120/1

Tomas Hudlicky was born in Prague, Czechoslovakia, and emigrated to the US in 1968. He received his PhD in 1977 under Professor Ernest Wenkert, and subsequently spent a year at the University of Geneva working under Professor Wolfgang Oppolzer on the synthesis of isocomene. He began his academic career in 1978 at the Illinois Institute of Technology, before moving to Virginia tech in 1982 and then the University of Florida in 1995. In 2003, he accepted a chair at Brock University where he is currently professor of organic synthesis and biocatalysis. Professor Hudlicky's research interests include the development of enantioselective synthetic methods, bacterial dioxygenase-mediated degradation of aromatics and the isolation of chiral metabolites for use in asymmetric synthesis.

Josephine Wiley Reed was born and raised in North Carolina, receiving her PhD under Professor David Kingston at Virginia Tech in 1988. She holds a BA in biology with chemistry minor from the Appalachian State University and a BA in English from the University of North Carolina in Greensboro. She has taught organic chemistry courses at Virginia Tech and has held the position of Senior Research Associate at Virginia Tech, University of Florida and Brock University since 1989. She has also served as the editorial assistant for the North American Editorial Office of J. Chem. Soc. Perkin Trans 1 and 2, as a member of the organizing committee for the Symposium on the Latest Trends in Organic Synthesis, and as a consultant to TDC Research, Inc, a custom synthesis company.

T. Hudlicky, Dept. of Chemistry, Brock University, St. Catharines, Canada; J. W. Reed, Dept. of Chemistry, Brock University, St. Catharines, Canada