ABOUT THE EDITORS vii

CONTRIBUTORS ix

INTRODUCTION 1

1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3
Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng

2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29
Guo-Qiang Lin and Xing-Wen Sun

3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77
Jianqiang Wang and Wenya Lu

4 RESOLUTION OF CHIRAL DRUGS 137
Qi-Dong You

5 FLUORINE-CONTAINING CHIRAL DRUGS 195
Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing

6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253
Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni

7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297
Deping Wang and Eric Hu

8 PHARMACOLOGY OF CHIRAL DRUGS 323
Yongge Liu and Xiao-Hui Gu

9 PHARMACOKINETICS OF CHIRAL DRUGS 347
Hanqing Dong, Xiaochuan Guo and Zengbiao Li

10 TOXICOLOGY OF CHIRAL DRUGS 381
Guang Yang and Hai-Zhi Bu

11 REPRESENTATIVE CHIRAL DRUGS 401
Jiangqin Sun, Dingguo Liu, and Zhimin Wang

INDEX 449

GUO-QIANG LIN, is a professor at the Shanghai Institute of Organic Chemistry and an adjunct professor at Fudan University, China. He is the Director of the Division of Chemical Science of the National Natural Science Foundation of China. Among Professor Lin's publications are the Wiley books Principles and Applications of Asymmetric Synthesis and Biocatalysis for the Pharmaceutical Industry.

QI-DONG YOU, PHD, is the Dean and a professor of the School of Pharmacy at China Pharmaceutical University. He is an Associate Editor of Progress in Pharmaceutical Sciences and serves on the Editorial Board of the International Journal of Medicinal Chemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor of over eighty publications, and an inventor or co-inventor of over twenty patent applications and patents.

JIE-FEI CHENG, PHD, is the Director of Otsuka Shanghai Research Institute, a fully owned subsidiary of Otsuka Pharmaceutical Co., Ltd Japan. Formerly an associate professor at Shanghai Institute of Organic Chemistry, he has worked for over fifteen years in the pharmaceutical and biotech industries in the United States. Dr. Cheng is a coauthor of over fifty peer-reviewed publications, and an inventor or coinventor of over twenty patent applications and patents.