Erythropoietin
Blood, Brain and Beyond

1. Auflage Januar 2004
XIII, 224 Seiten, Hardcover
30 Abbildungen (10 Farbabbildungen)
3 Tabellen
Monographie
Kurzbeschreibung
Die neuesten Erkenntnisse über Erythropoietin, seine Wirkung und medizinische Einsatzmöglichkeiten wurden in diesem Band zusammengetragen. Zahlreiche Abbildungen und Farbtafeln lassen verschiedenste Aspekte von der Entwicklungsbiologie, den Wirkmechanismen und Struktur-Aktivitäts-Beziehungen bis zur Anwendung von rekombinantem Epo und anderen therapeutisch relevanten Themen lebendig werden.
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The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system.
Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents.
The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
2. Developmental Biology of Erythropoiesis and Erythropoietin Production
3. Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia Dependent Genes
4. Physiology and Metabolism of Erythropoietin
5. Biochemistry and Protein Structure
6. Receptor Biology and Signal Transduction
7. Clinical Disorders of Erythropoietin and its Receptor
8. Recombinant Erythropoietin and the Treatment of Anemia
9. Function of Erythropoietin Outside of Hematopoiesis
10. Erythropoietin and Sport
11. The Future of Erythropoietin
Arzneimittel-Forschung
Current research interests include therapeutic protein engineering, the control of blood cell differentiation, mechanisms of neoplasia, biological effects of microgravity, ligand/receptor biochemistry, growth factor signal transduction, gene regulation and cancer chemoprevention.