Preface xv

Part 1 Foundations

12 Metabolism and Bioenergetics 351

1 The Chemical Basis of Life 1

2 Aqueous Chemistry 27

Part 2 Molecular Structure and Function

3 Nucleic Acid Structure and Function 57

4 Amino Acid and Protein Structure 87

5 Protein Function 127

6 Enzymes: Classification and Catalysis 169

7 Enzyme Kinetics and Inhibition 203

8 Lipids and Biological Membranes 241

9 Membrane Transport 269

10 Signaling 299

11 Carbohydrates 327

Part 3 Metabolism

12 Metabolism and Bioenergetics 351

13 Carbohydrate Metabolism 381

14 The Citric Acid Cycle 419

15 Oxidative Phosphorylation 443

16 Photosynthesis 473

17 Lipid Metabolism 499

18 Nitrogen Metabolism 535

19 Regulation of Mammalian Fuel Metabolism 571

Part 4 Genetic Information

20 DNA Replication and Repair 597

21 Transcription and RNA Processing 641

22 Protein Synthesis 677

CHARLOTTE PRATT received a B.S. in biology from the University of Notre Dame and a Ph.D. in biochemistry from Duke University. She is a protein chemist who has conducted research in blood coagulation and inflammation at the University of North Carolina at Chapel Hill. She is currently Associate Professor in the Biology Department at Seattle Pacific University. Her interests include molecular evolution, enzyme action, and the relationship between metabolic processes and disease. She has written numerous research and review articles, has worked as a textbook editor, and is a co-author, with Donald Voet and Judith G. Voet, of Fundamentals of Biochemistry, published by John Wiley & Sons, Inc.

KATHLEEN CORNELY holds a B.S. in chemistry from Bowling Green (Ohio) State University, an M.S. in biochemistry from Indiana University, and a Ph.D. in nutritional biochemistry from Cornell University. She is currently the Robert H. Walsh '39 Endowed Professor in Chemistry and Biochemistry at Providence College, where she has focused on expanding the use of case studies and guided inquiry across a broad spectrum of classes. Her interest in active pedagogy has led to her involvement in national programs including Project Kaleidoscope, the POGIL Project, and the Howard Hughes Medical Institute SEA PHAGES program, which has also fueled her current experimental research in phage genomics. She has been a member of the editorial board of Biochemistry and Molecular Biology Education and has served for several years as coordinator of the undergraduate poster competition at the annual meeting of the American Society for Biochemistry and Molecular Biology.

C. W. Pratt, University of Notre Dame; Duke University; University of North Carolina at Chapel Hill; Seattle Pacific University; K. Cornely, Ohio State University; Indiana University; Cornell University; Providence College