Medicinal Chemistry of Bioactive Natural Products
1. Auflage April 2006
480 Seiten, Hardcover
Praktikerbuch
Kurzbeschreibung
Featuring contributions by some of the world's leading scientists in the field, Medicinal Chemistry of Bioactive Natural Products contains articles dealing with discovery, structure elucidation, and elegant synthetic strategies developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The topics in this book are selected carefully since bioactive natural products are clinically useful pharmaceuticals or the primary compounds under extensive medicinal chemistry exploration. The book provides examples with updated research results while also bringing a historical perspective to the chemistry and biology of some selected bioactive compounds, a technique which could inform researchers about the process of developing pharmaceuticals, from discovery to application as drugs.
Current discoveries and research into bioactive natural products
Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.
Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.
Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics
Contributors.
1 The Chemistry and Biology of Epothilones--Lead Structures for the Discovery of Improved Microtubule Inhibitors (Karl-Heinz Altmann).
Acknowledgments.
References.
2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives (Roderich D. Su¨ssmuth).
Acknowledgment.
References.
3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs (Wei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang).
Acknowledgments.
References.
4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease (Da-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li).
Abbreviations.
References.
5 Qinghaosu (Artemisinin)--A Fantastic Antimalarial Drug from a Traditional Chinese Medicine (Ying Li, Hao Huang, and Yu-Lin Wu).
References.
6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of Sarcophyton Genus (Yulin Li, Lizeng Peng, and Tao Zhang).
Acknowledgments.
References.
7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba (Kristian Strømgaard).
Acknowledgment.
References.
8 Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents (Lin Wang, Tao Ma, and Gang Liu).
References.
9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs (Donglei Yu and Kuo-Hsiung Lee).
Acknowledgments.
References.
10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modified Mimics (Tai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao).
References.
Index.
"...I can imagine this book being used in an interdisciplinary graduate course...[or] as a reference text." (Journal of the American Chemical Society, September 13, 2006)
"The authors are to be commended on the excellent blending of chemical, biological, and pharmacologic data...highly recommended to all with an interest in medicinal natural products chemistry." (Journal of Medicinal Chemistry, June 1, 2006)
WEI-SHUO FANG graduated from Beijing Medical University, and obtained his PhD degree from Peking Union Medical College (PUMC) in 1997. After postdoctoral training in the US, he joined the faculty of the Institute of Materia Medica, Chinese Academy of Medical Sciences & PUMC. He has conducted visiting study in the University of Illinois at Urbana-Champaign and coauthored more than thirty articles in peer-reviewed journals.