The Genetics and Biology of Sex Determination
Novartis Foundation Symposium
März 2002
276 Seiten, Hardcover
Wiley & Sons Ltd
Nature employs a wide variety of sex determining mechanisms and it
is only comparatively recently that the tools have become available
for these to be explored at the cellular and molecular
levels. A major landmark was the discovery in 1990 of the
SRY gene and the subsequent demonstration of its key role in
triggering male sex determination in transgenic mice.
This book reviews and discusses our current understanding of the
molecular genetic pathways of sex determination, with special
emphasis on vertebrates. It features comparisons with other
modes of sex determination, consideration of the biology of sexual
development and discussion of the evolution of sex-determining
mechanisms.
By bringing together an international and interdisciplinary
group of experts who study many different aspects of the problem,
the book highlights much new and exciting work in this area and
serves to identify and stimulate promising new research
directions.
Sex-determining genes in mice: building pathways (R. Lovell-Badge,
et al.).
Early gonadal development: exploring Wtl and Sox9 function (J. Guo,
et al.).
General Discussion I: The mechanism of action of SRY.
Anomalies of human sexual development: clinical aspects and genetic
analysis (E. Vilain).
The molecular action of testis-determining factors SRY and SOX 9
(V. Harley).
Concerted regulation of gonad differentiation by transcription
factors and growth factors (T. Suzuki, et al.).
General Discussion II.
Evolution of the testis-determining gene - the rise and fall of SRY
(Marshall Graves).
A Comparative Analysis of vertebrate Sex Determination (A.
Sinclair, et al.).
Invertebrates may not be so different after all (D.
Zarkower).
The hormonal control of sexual development (M. Renfree, et
al.).
Genetic studies of MIS signalling in sexual development (S. Jamin,
et al.)
Social regulation of the brain: sex, size and status (R.
Fernald).
The battle of the sexes: opposing pathways in sex determination (H.
Hung-Chang Yao, et al).
General Discussion III: True Hermaphroditism and the Formation of
the Ovotestis.
The evolution of chromosomal sex determination (B.
Charlesworth).
The molecular genetic jigsaw puzzle of vertebrate sex determination
and its missing pieces (G. Scherer).
Expression-based strategies for discover of genes involved in
testis and ovary development (P. Koopman, et al.).
Final General Discussion.
Index of Contributors.
Subject Index.