The Septins
1. Auflage November 2008
380 Seiten, Hardcover
Lehrbuch
Kurzbeschreibung
Septin proteins hold increasing importance in a diverse areas of research, including cell biology, genetics, medicine and pathology. Featuring contributions from key investigators in this area, The Septins provides a timely overview of septin proteins and presents the most cutting-edge research to date. The only book currently available on the subject, the text discusses septins in different model organisms, septin evolution, genomics, and biochemistry, and explains the relationship between septins and signaling pathways in addition to human disease and stress responses, making this an invaluable resource for researchers and graduate students in the field.
Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions.
The Septins is the first comprehensive book devoted to the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila.
A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed.
In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences.
The Septins is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.
Authors and Affiliations vii
An introduction to the septins 1
Peter A. Hall, S. E. Hilary Russell and John R. Pringle
Section I Setting the scene 5
Chapter 1 Origins and development of the septin field 7
John R. Pringle
Chapter 2 Evolution and conserved domains of the septins 35
Michelle Momany, Fangfang Pan and Russell L. Malmberg
Section II Septins in model systems 47
Chapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49
Michael A. McMurray and Jeremy Thorner
Chapter 4 Yeast septins: a cortical organizer 101
Yves Barral
Chapter 5 Septins in four model fungal systems: diversity in form and function 125
Amy Gladfelter and Peter Sudbery
Chapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147
Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen Oegema
Section III Septins in mammals 169
Chapter 7 The genomics and regulation of the human septin
genes 171
S.E. Hilary Russell
Chapter 8 The functions of septins in mammals 187
Carol D. Froese and William S. Trimble
Chapter 9 Septin-interacting proteins in mammals 211
Brandon E. Kremer and Ian G. Macara
Chapter 10 Septin functions in the mammalian cytoskeleton 229
Elias T. Spiliotis and W. James Nelson
Chapter 11 Septins and the synapse 247
Jing Xue, Victor Anggono and Phillip J. Robinson
Chapter 12 Septins and platelets 269
Jerry Ware, Constantino Mart´1nez and Barbara Zieger
Chapter 13 Septins and apoptosis 281
Marie-Jeanne Carp and Sarit Larisch
Chapter 14 Septins and human disease 295
Peter A. Hall and Fern P. Finger
Chapter 15 Insight into septin functions from mouse models 319
Makoto Kinoshita
Section IV Envoi 337
Chapter 16 Septins: 2008 and beyond 339
Peter A. Hall, S.E. Hilary Russell and John R. Pringle
Appendix A Septin and septin-like sequences 343
Michelle Momany, Fangfang Pan and Russell L. Malmberg
Appendix B Mammalian septin nomenclature 351
Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. Pringle
Appendix C Septin meetings and workshops 355
Peter A. Hall and John R. Pringle
Index 361