Therapeutic Oligonucleotides

The potential for the development of therapeutic oligonucleotides
into clinical medicines and their use as basic research tools are
explored in this volume, which is the proceedings of the 7th NIH
Symposium on Therapeutic Oligonucleotides. The focus is on
antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG
immune modulatory oligonucleotides.



Specific chapters address designing better siRNAs, splice
switching oligonucleotides, selective delivery of oligonucleotides,
and medicinal drugs by receptor-mediated endocytosis, development
of a function overriding siRNA silencing in mammalian cells,
transcription factor decoys, and modified oligonucleotide
hybridization and genetic insertion.

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