Transporters as Drug Carriers
Structure, Function, Substrates
Methods and Principles in Medicinal Chemistry (Band Nr. 44)
1. Auflage Oktober 2009
XX, 429 Seiten, Hardcover
10 Abbildungen (10 Farbabbildungen)
Handbuch/Nachschlagewerk
Kurzbeschreibung
The first overview on the molecular basis of drug resistance is a key resource for anyone working with antibiotics and cancer chemotherapeutics. Also of prime interest for biochemists and biophysicists, due to its systematic characterization of all known transporter classes.
Dieser Band aus der Reihe "Methods and Principles in Medicinal Chemistry" beleuchtet die Rolle molekularer Wirkstofftransporter im Kontext der Therapieoptimierung und der Aufklärung von Wirkstoffresistenzen. Alle bekannten Transporterklassen (vom Mikroorganismus bis zum Menschen) werden vorgestellt.
1 The ABC Transporters: Structural Insights into Drug Transport
2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters
3 Organic Anion Transporting Polypeptides (Oatps/OATPs)
4 CNS Transporters as Drug Targets
PART 2
5 Bacterial Multidrug Transporters: Molecular and Clinical Aspects
6 Pleiotropic drug resistance in yeast and fungal pathogens
PART 3
7 QSAR studies on ABC-transporters: how to deal with polyspecificity
8 Drug Transporter Pharmacophores
PART 4
9 Biological Membranes and Drug Transport
10 Transport at the Blood-Brain Barrier
11 Bile canalicular transporters
12 Interplay of Cytochrome P450 Isoenzymes and ABC-transporter
13 ABC-Transporter: From target to antitarget
PART 3
14 A Systems Biology View of Drug Transporters
15 Drug Transporters in Health and Disease
Peter Chiba is a senior scientist and lecturer at the Medical University of Vienna. He holds a doctorate in Medicine from the University of Vienna and worked at the Universities of Nijmegen (The Netherlands) and South Florida (USA) as a Fulbright scholar and post-doctoral associate. His research focuses on multidrug transport and resistance to drugs in treatment of cancer and microbial disease.