Protein Homeostasis in Drug Discovery
A Chemical Biology Perspective
1. Auflage November 2022
560 Seiten, Hardcover
Wiley & Sons Ltd
Weitere Versionen
Protein Homeostasis in Drug Discovery
Comprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field
Protein Homeostasis in Drug Discovery highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein's activity may not be the only factor to consider when developing therapeutic agents.
The chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality.
Readers interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, those interested in the link between biological function and regulating protein levels in living organisms, especially in the context of drug discovery, will learn from numerous examples discussed in this book.
In Protein Homeostasis in Drug Discovery, readers can expect to find information on:
* Protein folding, quality control, pharmacology, and drug targeting processes
* Recent advances in our understanding of protein homeostasis, covering emerging technologies and opportunities for therapeutic intervention
* Targeted protein degradation (TPD) and strategies such as PROTACs and molecular glues, including a chapter on TPD as an antiviral drug discovery strategy
* Drug discovery and development efforts aimed at correcting, stabilizing, and rescuing proteins, with examples included
* Advantages and key shortcomings of both phenotypic and target-based traditional drug discovery methods
Collectively, Protein Homeostasis in Drug Discovery offers the reader an opportunity to learn more about the importance of considering and targeting protein homeostasis. The text is a must-read resource for academics, professionals in the pharmaceutical industry, and advanced students in various science-related fields.
Chapter - 1 : Epichaperomes as a gateway to understanding, diagnosing, and treating disease through rebalancing protein-protein interaction networks
Chander S. Digwal, Sahil Sharma, Anand R. Santhaseela, Stephen D. Ginsberg, and Gabriela Chiosis,
Chapter - 2 : Stability of Steroid Hormone Receptors: The Intersection of Proteostasis and Selective Degradation
Zachary J. Gale-Day and Jason E. Gestwicki
Chapter - 3: Pharmacological Chaperones; therapeutic potential for diseases resulting from GPCR misfolding
Suli-Anne Laurin, Sajjad Ahrari, and Michel Bouvier
SECTION II: Protein Degradation and Clearance as Drug Targeting Opportunities
Chapter - 4: Exploiting the proteasome for disease treatment: from dynamic architecture to vast functions
Gwen R. Buel, Xiuxiu Lu, and Kylie J. Walters
Chapter - 5: Targeting the ubiquitination cascade for drug discovery
Qi Liu, Gabriel LaPlante, and Wei Zhang
Chapter - 6: Understanding, targeting and hijacking autophagy
Hongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, and Lingzhi Ye,
Chapter - 7: Deubiquitinating enzymes: from undruggable targets to emerging opportunities
Ariana Jones, Xiaoxi Liu, Anthony Varca, Lara Doherty, and Sara Buhrlage
SECTION III: Redirecting Protein Degradation Processes for Drug Development
Chapter - 8: History of IMiDs and protein degradation as a pharmacological modality
Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, and Hiroshi Handa
Chapter - 9: PROTAC Degraders: Mechanism, Recent Advances and Future Challenges
Alessio Ciulli and Oliver Hsia
Chapter - 10: Biochemical principles of targeted protein degradation
Roman V. Agafonov, Richard W. Deibler, W. Austin Elam, Joe Sahil Patel, and Stewart L. Fisher
Chapter - 11: Pharmacology of PROTAC degrader molecules: optimizing for in vivo performance
Andy Pike, Sofia Guzzetti, Pablo Morentin Gutierrez, and James S. Scott
SECTION IV: Emerging technologies and future opportunities
Chapter - 12: Proximity-inducing bifunctional molecules beyond PROTACs
Sophia Lai, Ashley E. Modell, and Amit Choudhary
Chapter - 13: Strategies for tag-based protein control
Behnam Nabet, Nathanael S. Gray, and Fleur M. Ferguson
Chapter - 14: Targeted protein degradation in antiviral drug discovery
Mélissanne de Wispelaere and Priscilla L. Yang
Chapter - 15: Beyond Inhibition: Ligand-Based Pharmacological Exploration as a Strategy Towards New Targets and Modalities
Milka Kostic and Lyn H. Jones
Lyn H. Jones, PhD, is currently Director of the Center for Protein Degradation at the Dana-Farber Cancer Institute and his interests include using chemogenomics and chemoproteomics to advance new therapeutic modalities.
