Computational Molecular Biology
An Introduction
Wiley Series in Mathematical and Computational Biology
1. Edition August 2000
XIV, 286 Pages, Softcover
Wiley & Sons Ltd
Short Description
The use of computer programming to model real-life biological systems involves the implementation of a wide variety of different algorithms and models, such as Monte-Carlo Methods and the use of Markov chains.
Recently molecular biology has undergone unprecedented development generating vast quantities of data needing sophisticated computational methods for analysis, processing and archiving. This requirement has given birth to the truly interdisciplinary field of computational biology, or bioinformatics, a subject reliant on both theoretical and practical contributions from statistics, mathematics, computer science and biology.
* Provides the background mathematics required to understand why certain algorithms work
* Guides the reader through probability theory, entropy and combinatorial optimization
* In-depth coverage of molecular biology and protein structure prediction
* Includes several less familiar algorithms such as DNA segmentation, quartet puzzling and DNA strand separation prediction
* Includes class tested exercises useful for self-study
* Source code of programs available on a Web site
Primarily aimed at advanced undergraduate and graduate students from bioinformatics, computer science, statistics, mathematics and the biological sciences, this text will also interest researchers from these fields.
Math Primer.
Sequence Alignment.
All About Eve.
Hidden Markov Models.
Structure Prediction.
Appendices.
References.
Index.
