Optimization in HPLC

Concepts and Strategies

Kromidas, Stavros (Editor)

1. Edition September 2021
XVIII, 398 Pages, Softcover
Practical Approach Book

ISBN: 978-3-527-34789-6

Wiley-VCH, Weinheim

Short Description

This handy guide provides detailed practical information for HPLC practitioners of all skill levels, enabling them to optimize the performace of their HPLC/UHPLC system for a wide range of analytical tasks.

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Content
Author information

PART 1: OPTIMIZATION STRATEGIES FOR DIFFERENT MODES AND USES OF HPLC
Working under regulatory constraints
Reverse phase gradient methods
2-Dimensional chromatography
HILIC
LC-MS
Biomolecules
Supercritical fluid chromatography
Chiral substances
Column selection for small molecules
Optimization based on analyte structure

PART 2: COMPUTER-AIDED OPTIMIZATION
ChromSword
DryLab
Fusion QbD
Quality by Design approaches to determine the robust range

PART 3: CURRENT CHALLENGES FOR HPLC USERS IN INDUSTRY
Big Chemistry
Big Analytical Service Providers
Small Analytical Service Providers

PART 4: CURRENT CHALLENGES FOR HPLC EQUIPMENT SUPPLIERS
Thermo Fisher Scientific
Agilent
Shimadzu
Waters
Knauer

Stavros Kromidas, PhD, works as an independent consultant for analytical chemistry, based in Saarbrucken (Germany). For more than 20 years he has regularly held lectures and training courses on HPLC, and has authored numerous articles and several books on various aspects of chromatography. He is the founder of NOVIA GmbH, a provider of professional training and consulting in analytical chemistry, and served as its CEO until 2001.