3. Edition April 2020
XXVIII, 620 Pages, Hardcover
Practical Approach Book
The third edition of this popular work is revised to include the latest developments in this fast-changing field. Its interdisciplinary approach elegantly combines the chemistry and engineering to explore the fundamentals and optimization processes involved.
FUNDAMENTALS AND GENERAL TERMINOLOGY
Principles of Adsorption Chromatography
Basic Effects and Chromatographic Definitions
Mass Transfer Phenomena
STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS
Selection of Chromatographic Systems
CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION
Challenges for Conceptual Process Design
Engineering and Operational Challenges
Commercial Chromatography Column
Commercial Chromatography Systems
Standard Process Control
Disposable Technology for Bio-separations
Choice of Process concepts
MODELING AND MODEL PARAMETERS
Models for Single Chromatographic Columns
Modeling HPLC Plants
MODEL BASED DESIGN, OPTIMIZATION AND CONTROL
Basic Principles and Definitions
Isocratic Batch Chromatography
Gradient Batch Chromatography
Conventional Isocratic SMB Chromatography
Isocratic SMB Chromatography under Variable Operating Conditions
Gradient SMB Chromatography
Practical Approaches for Design of SMB Chromatography
Process Configuration and Optimization by Superstructures
Advanced Process Control
"Overall the coverage is a bit uneven - nevertheless the volume does compile some useful material... In conclusion, this is a comprehensive reference text, which should find its way into the libraries of all companies who are serious about process scale preparative chromatography, whether internally or via outsource contracts."
Organic Process Research and Development
"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes."
Advances in Food Sciences
Prof. Seidel-Morgenstern is the Director of the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany and holds the Chair in Chemical Process Engineering at the Otto-von-Guericke-Universität, Magdeburg, Germany. He received his Ph.D. in 1987 at the Institute of Physical Chemistry of the Academy of Sciences in Berlin. From there he went on to work as postdoctoral fellow at the University of Tennessee, Knoxville, USA. In 1994 he finished his habilitation at the Technical University in Berlin. His research is focused on new reactor concepts, chromatographic reactors, membrane reactors, adsorption and preparative chromatography and separation of enantiomers amongst others.
Dr. Michael Schulte is Senior Director Emerging Businesses Energy at Merck KGaA Performance Materials, Darmstadt, Germany. In his Ph.D. thesis at the University of Münster, Germany, he developed new chiral stationary phases for chromatographic enantioseparations. In 1995 he joined Merck and has since then been responsible for research and development in the area of preparative chromatography, including the development of new stationary phases, new separation processes and the implementation of Simulated Moving Bed-technology at Merck. In his current position one of his areas of research is the use of Ionic Liquids for separation processes.