Microreactors in Preparative Chemistry

PREFACE

PRINCIPLES OF MICROPROCESS TECHNOLOGY
Introduction
History
Basic Characteristics
Industrial Applications
Concluding Remarks

EFFECTS OF MICROFLUIDICS ON PREPARATIVE CHEMISTRY PROCESSES
Introduction
Mixing
Heat Management
Mass Transfer and Chemical Reactions
Flow Separation
Numbering-Up Strategy
Practical Exercise: Experimental Characterization of Mixing in Microstructured Reactors

MODULAR MICRO- AND MILLIREACTOR SYSTEMS FOR PREPARATIVE CHEMICAL SYNTHESIS AND BIOPROCESSES
Introduction
Modular Microreaction System
Examples for Microreactor Applications
Laboratory Exercise: Suzuki Reaction in a Modular Microreactor Setup

POTENTIAL OF LAB-ON-A-CHIP: SYNTHESIS, SEPARATION, AND ANALYSIS OF BIOMOLECULES
Introduction
Learning from Nature: Analogies to Living Cells
Microenzyme Reactors
Microchip Electrophoresis
Microenzyme Membrane Reactor/Micromembrane Chromatography
Nucleic Acid Analysis in Microchannels
Saccharide Analyses in Microdevices
Practical Exercise: Lipase-Catalyzed Esterification Reaction

BIOPROCESSING IN MICROREACTORS
Introduction
Background
Practical Exercise: Functionalization of Silicon Surface

SYNTHESIS OF FINE CHEMICALS
Introduction
Organic Synthesis in Liquid and Liquid - Liquid Phases
Gas - Liquid Biphasic Organic Synthesis
Practical Exercise: Photochemical Generation of Singlet Oxygen and Its [4 + 2] Cycloaddition to Cyclopentadiene

SYNTHESIS OF NANOMATERIALS USING CONTINUOUS-FLOW MICROREACTORS
Introduction
Microfluidic Devices
Synthesis of Nanomaterials Using Microreactors
Kinetic Studies
Process Optimization
Point-of-Use Synthesis and Deposition
Practical Exercises: Synthesis of Nanocrystals

POLYMERIZATION IN MICROFLUIDIC REACTORS
Introduction
Practical Considerations
Single-Phase Polymerization
Multiphase Polymerization
Beyond Synthesis: New Developments for Next-Generation MF Polymerization
Practical Exercise: MF Polymerization Reactor Kinetics Studies Using In Situ Characterization

ELECTROCHEMICAL REACTIONS IN MICROREACTORS
Introduction
Electrode Configuration
Electrolysis without Supporting Electrolytes
Generation and Reactions with Unstable Intermediates
Practical Exercise: Electrochemical Reactions in Flow Microreactors

HETEROGENEOUS CATALYSIS IN MICROREACTORS
Introduction
Bulk Catalysts
Supported Catalysts
Mesoporous Supports
Microporous Supports
Practical Exercise: PdZn/TiO2-Catalyzed Selective Hydrogenation of Acetylene Alcohols in a Capillary Microreactor

CHEMICAL INTENSIFICATION IN FLOW CHEMISTRY THROUGH HARSH REACTION CONDITIONS AND NEW REACTION DESIGN
Introduction
High-Temperature Processing in Microflow
High-Pressure Processing in Microflow
Solvent Effects in Microflow
Ex-Regime Processing and Handling of Hazardous Compounds in Microflow
New Chemical Transformations in Microflow
Process Integration in Microflow
Practical Exercises

MODELING IN MICROREACTORS
Introduction
Processes in Microreactors and the Role of Mixing
Modeling of Processes in Microreactors Based on General Balance Equation
Computation of Reaction Flows in Microreactors
Practical Exercise: Alkylation of Phenylacetonitrile

INDEX

Wladimir Reschetilowski is Director of the Institute of Industrial Chemistry at the University of Technology Dresden, Germany. Having obtained his academic degrees from Technical University Leuna-Merseburg, he began his career working at the Leipzig University, continued it for DECHEMA (Society for Chemical Engineering and Biotechnology, Frankfurt/M.) as the Head of the Department of Technical Chemistry before taking up his present appointment as Full Professor at the University of Technology Dresden. Professor Reschetilowski has authored over 200 scientific publications in the field of acid and bifunctional catalytic conversion of hydrocarbons by microporous and mesoporous solids, asymmetric synthesis on chiral-modified catalyst systems, application of microstructured reactors in preparative chemistry and catalytic
conversion of bio-based raw materials into organic base products and fuels. He is awarded with an honorary professorship by St.-Petersburg State University of Technology and is known as the principal author of the compendium 'Academic curriculum of teaching technical chemistry' in German Universities as well as of the teaching book 'Technisch-chemisches Praktikum'. He is also appointed expert of the accreditation agency in engineering, computer sciences, natural sciences and mathematics (ASIIN).

W. Reschetilowski, Dresden University of Technology, Dresden, Germany