Histocompatibility and Immunogenetics

A Guide for Practitioners

Oberle, Volker (Editor)

1. Edition November 2025
592 Pages, Hardcover
100 Pictures (91 Colored Figures)
Practical Approach Book

Short Description

The authoritative guide to concepts, methods and applications in matching donors and acceptors of transplanted cells and organs for medical researchers and practitioners, with participation by EFI and ASHI.

ISBN: 978-3-527-35402-3

Wiley-VCH, Weinheim

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By providing an authoritative introduction to concepts, methods and applications in matching donors and acceptors of transplanted cells and organs, this guide provides medical researchers and practitioners with the key knowledge for performing meaningful histocompatibility analyses and thereby improving the outcome of transplantation therapies across all medical fields. The authors are all members of the European and/or American Societies for Immunogenetics and have been instrumental in developing commonly accepted standards and therapeutic recommendations.

Part 1: BIOLOGICAL BASICS
(1) Innate Immune Defence
(2) Specific Immune Defence
(3) The HLA/MHC System
(4) The HNA System
(5) Natural Killer Cell Receptors
(6) The HPA System
(7) Other Polymorphic Systems

Part 2: CLINICAL APPLICATIONS
(8) Basic Concepts of Organ Transplantation
(9) Basic Concepts of Organ Rejection
(10) Treatment of Organ Rejection
(11) Stem Cell Transplantation
(12) Stem Cell Transplantation from Unrelated Donors
(13) Chimerism Testing in Stem Cell Transplantation
(14) Disease Associations with HLA Alleles
(15) Drug Associations with HLA Alleles
(16) Diseases in the Field of Transfusion Medicine

Part 3: METHODS IN HISTOCOMPATIBILITY AND IMMUNOGENETICS
(17) Isolation and Purification of Test Material
(18) HLA-Antibody Determination
(19) Low/ medium-resolution HLA typing
(20) High-resolution HLA Typing
(21) Crossmatching in Transplantation
(22) Determination of Antibodies and Typing in the HPA System
(23) KIR Genotyping
(24) Determination of Antibodies and Typing in the HNA System
(25) Determination and Typing of Other Polymorphic Systems

Part 4: REGULATORY ASPECTS
(26) Regulations in Histocompatibility and Immunogenetics: Accreditation, External Proficiency Testing, Quality Management
Glossary and Index

Volker Oberle is the Director of the EFI laboratory for transplantation immunology at Jena University Hospital. He studied Chemistry and Biochemistry at the universities of Freiburg and Halle-Wittenberg and did postdoctoral research at the University Medical Center Groningen before moving to Jena in 2003.