Anticancer Therapeutics
1. Edition November 2008
424 Pages, Hardcover
Professional Book
Short Description
Written by the winner of the 2008 Mike Price Fellowship
The need to re-address known anti-cancer agents and discover new ones are of paramount importance. Anticancer Therapeutics provides a comprehensive overview of the wealth of information currently available on this important and fast-moving subject. The book provides a clear introduction to the area, with a historical overview of initial developments of cancer therapeutics and their progress in today's multidisciplinary approach to cancer treatment. Coverage includes currently used mainline molecular treatment approaches as well as "the drugs of tomorrow," making this an invaluable resource for postgraduates and researchers.
Written by the winner of the 2008 Mike Price Fellowship
Anticancer Therapeutics provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject. The book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today's multidisciplinary approach to cancer treatment.
Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow.
The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design.
Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.
Preface.
SECTION I: DEVELOPMENT OF ANTICANCER THERAPEUTICS.
1. Exploring the potential of natural products in cancer treatment (Fotini N. Lamari and Paul Cordopatis).
2. Combinatorial approach to anticancer drug design (Sotiris Missailidis).
3. Rational approaches to anticancer drug design/in silico drug development (Stefano Alcaro, Anna Artese and Francesco Ortuso).
SECTION II: ANTICANCER THERAPEUTICS.
4. Introduction (Teni Boulikas).
5. Platinum drugs (Teni Boulikas, Alexandros Pantos, Evagelos Bellis and Petros Christofis).
6. Antimicrotubule agents (Iain Brown, Jay N Sangrithi-Wallace and Andrew C Schofield).
7. Antimetabolites in cancer therapy (Jessica Scaiffe and David Kerr).
8. Antitumour antibiotics (Manuel M. Paz).
9. Alkylating agents (Ana Paula Francisco, Maria de Jesus Perry, Eduarda Mendes and Rui Moreira).
10. Hormone therapies (George C. Zografos, Nikolaos V. Michalopoulos and Flora Zagouri).
11. Photodynamic therapy of cancer (K. Eszter Borbas and Dorothée Lahaye).
12. Target-directed drug discovery (Tracey Bradshaw).
13. Tumour hypoxia: a malignant mediator (Jill L. O'Donnell, Aoife M. Shannon, David Bouchier-Hayes).
14. Resistance to chemotherapy drugs (Robert O?Connor and Laura Breen).
15. Cancer immunotherapy (Maria Belimezi).
16. Gene therapy (Maria Belimezi, Teni Boulikas and Michael L. Roberts).
17. Antisense agents (Huma Khan and Sotiris Missailidis).
18. Aptamers as anticancer agents (Vaidehi Makwana, Suzanne Simmons and Sotiris Missailidis).
SECTION III: OTHER ASPECTS IN ANTICANCER THERAPEUTIC DEVELOPMENT.
19. Treatment of cancer in conjunction with other agents (Gary Robert Smith).
20. Clinical trials in oncology (Tim Friede, Janet Dunn and Nigel Stallard).
21. Representative cancers, treatment and market (Teni Boulikas).
22. Conclusions and prospects (Sotiris Missailidis).
04707231063ENIntroduction.
1. Can Computer Games Affect Your Health?
2. Can Computer Games Change the Way You Think?
3. Can Computer Games Change Who You Are?
4. Can Computer Games Turn You Into an Addict?
5. Can Computer Games Make You Violent?
6. Can Computer Games Change the Way You Learn?
7. Can Computer Games Change Your Beliefs?
8. Can Computer Games Change Your Future?
Index.