Inositol Phospholipid Signaling in Physiology and Disease, Volume 1280
Annals of the New York Academy of Sciences
1. Edition May 2013
252 Pages, Softcover
Wiley & Sons Ltd
A recent upsurge of research examining inositol phospholipids
(IP)--membrane-bound species fundamental to cell
signaling--continues underscore the role of this pathway in
both normal and disease-associated cellular physiology. This
volume includes a selection of cutting-edge, multidisciplinary
reports borne out of the conference "Inositol Phospholipid
Signaling in Physiology and Disease" held June 26-27,
2012 at the New York Academy of Sciences in New York City.
Papers include important developments investigating IP signaling in
immunology, cancer, inflammation, and metabolic disorders.
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and Disease v
William G. Kerr and Sandra Fernandes
Phosphoinositide 3-kinase and INPP4B in human breast cancer
1
Micka C. Bertucci and Christina A. Mitchell
Role of SHIP1 in cancer and mucosal inflammation 6
Sandra Fernandes, Sonia Iyer, and William G. Kerr
Role of SHIP1 in bone biology 11
Sonia Iyer, Bryan S. Margulies, and William G. Kerr
Achieving cancer cell death with PI3K/mTOR-targeted therapies
15
Sung Su Yea and David A. Fruman
Challenges in the clinical development of PI3K inhibitors
19
Cristian Massacesi, Emmanuelle di Tomaso, Nathalie Fretault, and
Samit Hirawat
Rules of engagement: distinct functions for the four class I
PI3K catalytic isoforms in immunity 24
Klaus Okkenhaug
Control of T cell tolerance by phosphatase and tensin homolog
27
Alexandria Huynh and Laurence A. Turka
Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation
30
Shigenori Nagai, Yutaka Kurebayashi, and Shigeo Koyasu
Targeting phosphoinositide 3-kinase delta for the
treatment of respiratory diseases 35
Srividya Sriskantharajah, Nicole Hamblin, Sally Worsley, Andrew
R. Calver, Edith M. Hessel, and Augustin Amour
Phosphoinositide 3-kinase gamma in T cell biology and disease
therapy 40
Wai-Ping Fung-Leung
Inhibition of phosphoinositide 3-kinase gamma attenuates
inflammation, obesity, and cardiovascular risk factors 44
Matthias P. Wymann and Giovanni Solinas
Class III PI3K Vps34: essential roles in autophagy, endocytosis,
and heart and liver function 48
Nadia Jaber and Wei-Xing Zong
Inpp4b is a novel negative modulator of osteoclast
differentiation and a prognostic locus for human osteoporosis
52
Jean Vacher