John Wiley & Sons Mammalian TRP Channels as Molecular Targets Cover Transient Receptor Potential (TRP) genes were originally identified as encoding critical components .. Product #: 978-0-470-86254-4 Regular price: $179.44 $179.44 In Stock

Mammalian TRP Channels as Molecular Targets

No. 258

Novartis Foundation

Novartis Foundation Symposium

Cover

1. Edition March 2004
286 Pages, Hardcover
Wiley & Sons Ltd

ISBN: 978-0-470-86254-4
John Wiley & Sons

Short Description

Transient Receptor Potential (TRP) genes were originally identified as encoding critical components of phototransduction in Drosophila. Since the discovery of the first mammalian transient receptor potential channel (TRPC) some eight years ago, more than 20 mammalian homologues have been reported. These ion channel proteins are widely distributed in tissues and appear to play a fundamental role in cell signaling, growth, and death, although their specific physiological functions are largely unknown. There is growing evidence to suggest that the primary TRPCs may be store-operated channels, but this remains controversial. This resource brings readers up-to-date on this emerging field of study.

Further versions

mobipdf

This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.

Chair's Introduction (J. Putney).

Molecular genetics of Drosophila TRP channels (C. Montell).

Mammalian TRPC channnel subunit assembly (W. Schilling and M. Goel).

TRPC channel interactions with calmodulin and IP3 receptors (M. Zhu & J. Tang).

Plasma membrane localizations of TRPC channels: role of caveolar lipid rafts (I. Ambudkar, et al.).

Assembly and gating of TRPC channels in signalling microdomains (P. Delmas).

General discussion I.

Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins (T. Gudermann, et al.).

Signalling mechanisms for TRPC3 channels (J. Putney, et al.).

Diversity of TRP channel activation (B. Nilius and T. Voets).

General discussion II.

Regulation of Drosophila TRP channels by lipid messengers (R. Hardie).

Control of TRPC and store-operated channels by protein kinase C (K. Venkatachalam, et al.).

TRPC4 and TRPC4 deficient mice (M. Freichel, et al.).

TRP channels as drug targets (S. Li, et al.).

Role of TRP channels in oxidative stress (K. Groschner, et al.).

Distribution of TRPC channels in a visceral sensory pathway (M. Buniel, et al.).

Emerging roles of TRPM channels (A. Fleig and R. Penner).

Final discussion.

Index of contributors.

Subject index.