Pharmaceutical Bioassays
Methods and Applications
1. Edition November 2009
522 Pages, Hardcover
Wiley & Sons Ltd
Short Description
This book covers the methods and applications of bioassays in pharmaceutical science to quantify drug activity and evaluate the validity of models. It demonstrates the numerous systems available and that each system interprets the activity of drug molecules in different ways. The authors discuss the various models put forward to link the experimental observations and the events taking place on a cell or molecular level between the drug and experimental object, providing the principal and technological guide for successful research of drug research and clinical therapy.
The definitive compendium of bioassay procedures and applications
A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models.
Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories.
Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students.
Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which:
* Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer's, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas
* Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity--a particularly significant consideration in the development of safe and tolerable medications
* Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher
* Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists
* Provides an informative analysis of pharmaceutical bioassay technologies and lab applications
Contributors.
1. Methods and Application of Anticancer Bioassays (Shiqi Peng).
References and Notes.
2. Methods and Application Antiviral Assay (Chunying Cui, Shiqi Peng and Ming Zhao).
References and Notes.
3. Methods and Application of Antitubercular Assay (Chunying Cui, Shiqi Peng and Ming Zhao).
Reference and Notes.
4. Methods and Application of Thrombus Related Assays (Ming Zhao).
References and Notes.
5. Methods and Application of Anticoagulation Assays (Ming Zhao).
References and Notes.
6. Methods and Application of Blood Pressure Related Assay (Ming Zhao).
References and Notes.
7. Methods and Application of Assays Related to Parkinson's Disease and Graves' Disease (Shiqi Peng).
References and Notes.
8. Methods and Application of Alzheimer's Disease Assay (Shiqi Peng).
References and Notes.
9. Methods and Application of Antiosteoporosis Assay (Ming Zhao).
References and Notes.
10. Methods and Application of Immunomodulating Assay (Shiqi Peng).
References and Notes.
11. Methods and Application of Anti-inflammatory Assays (Ming Zhao).
References and Notes.
12. Methods and Application of Antioxidant Activity Assay (Shiqi Peng).
References and Notes.
13. Methods and Application of Analgesic Assays (Ming Zhao).
References and Notes.
14. Methods and Application of Epilepsy Assays (Ming Zhao, Shiqi Peng and Guohui Cui, ).
References and Notes.
15. Methods and Application of Diabetes Assay (Ming Zhao, Shiqi Peng and Guohui Cui).
References.
16. Methods and Application of Assay for Toxins from Microorganism (Shiqi Peng).
References and Notes.
17. Methods and Application of Toxicity Assay for Chemicals (Shiqi Peng).
References and Notes.
18 Methods and Application of Hepatoxicity and Hepatoprotective Assay (Shiqi Peng).
References and Notes.
19 Methods and Applications of Estrogen Assays (Shiqi Peng).
References and Notes.
20 Methods and Applications of Antimalarial Assays (Shiqi Peng).
References.
21 Methods and Applications of Cytogenetic Receptor and Enzyme Assays (Shiqi Peng).
References and Notes.
Ming Zhao is a Professor and Vice Dean at the School of Chemical Biology and Pharmaceutical Sciences of Capital Medical University in Beijing. She is the author of over 120 journal articles, seven books in China, and over 110 Chinese patents.
