Principles of Process Research and Chemical Development in the Pharmaceutical Industry
1. Edition January 1998
240 Pages, Hardcover
Wiley & Sons Ltd
Short Description
The purpose of process research and development is to transform a research synthetic procedure into a large-scale plant process. In essence, it involves taking a few milligrams of a drug, pesticide or chemical and redesigning the steps to accommodate large scale production of the substance. This book covers the key aspects of synthesis that must be considered when scaling up a process. It discusses such topics as minimizing by-product impurities, synthesizing enantipure compounds, criteria for an ideal cost effective synthesis and licensing.
This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
Impure Thoughts.
Going All the Way.
Resolutions.
Mirrors.
Au Naturel.
Radiant.
License.
The Future.
Index.
