Thermal Biophysics of Membranes
Tutorials in Biophysics (Series Nr. 1)
1. Edition July 2007
XV, 363 Pages, Hardcover
199 Pictures
19 tables
Monograph
Short Description
An overview of recent, previously unpublished experimental and theoretical developments in the physics of membranes, including new insights from the past decade.
Written with both students and researchers of biophysics, biochemistry, physical chemistry, and soft matter physics in mind.
An overview of recent experimental and theoretical developments in the field of the physics of membranes, including new insights from the past decade.
The author uses classical thermal physics and physical chemistry to explain our current understanding of the membrane. He looks at domain and 'raft' formation, and discusses it in the context of thermal fluctuations that express themselves in heat capacity and elastic constants. Further topics are lipid-protein interactions, protein binding, and the effect of sterols and anesthetics. Many seemingly unrelated properties of membranes are shown to be intimately intertwined, leading for instance to a coupling between membrane state, domain formation and vesicular shape. This also applies to non-equilibrium phenomena like the propagation of density pulses during nerve activity.
Also included is a discussion of the application of computer simulations on membranes.
For both students and researchers of biophysics, biochemistry, physical chemistry, and soft matter physics.
2. Membrane Structure
3. The Composition of Biological Membranes
4. Introduction into Thermodynamics
5. Water
6. Lipid Melting
7. Phase Diagrams
8. Statistical Models for Lipid Melting
9. Lipid-Protein Interactions
10. Diffusion
11. Electrostatics
12. Adsorption, Binding and Insertion of Proteins
13. Elasticity and Curvature
14. Thermodynamics of the Elastic Constants
15. Structural Transitions
16. Relaxation Processes in Membranes
17. Permeability
18. Nerve Pulse Propagation
19. Anesthesia
His primary research interests are experimental and theoretical thermodynamics and spectroscopy of artificial and biological membranes with a special focus on cooperative phenomena in biomembranes.