Birth Asphyxia and the Brain
Basic Science and Clinical Implications
1. Edition May 2002
432 Pages, Hardcover
Wiley & Sons Ltd
This text presents a state-of-the-art review of asphyxial brain
injury to the foetus and new born, a leading source of both
neonatal mortality and long-term neurologic disability. Beginning
with an historical overview of birth-related injury, followed by an
epidemiologic review of the relationship of birth injury to later
neuromotor disability, it provides a detailed analysis and
exhaustive review of each aspect. The contributors are among the
most knowledgeable international authorities in the field; they
have synthesized a uniformity of medical and scientific quality,
clarity of style, and thoroughness of scope. Continual emphasis is
placed on the material's relevance and usefulness to clinicians;
equally important is the emphasis on communication between
clinicians and basic neuroscientists.
The task of paediatricians and neonatologists in coming years
will be to better understand the mechanism of brain damage, the
prediction of disability, and the introduction of efficacious
neuroprotective strategies. To that end, this volume deserves wide
recognition by physicians in all disciplines related to neonatal
care, including paediatricians, neonatologists, neurologists,
obstetricians, family practitioners, nurses and legal counsel.
Harvey B. Sarnat.
Part I. History and Epidemiology.
Chapter 1. Cerebral Palsy and Its Causes: Historical
Perspectives.
Tonse N.K. Raju.
Chapter 2. The Relationship of Birth Asphyxia to Later Motor
Disability.
Michael P. Collins, Nigel S. Paneth.
.
Part II. Basic Science.
.
Chapter 3. The Biochemical Neurotoxic Cascade in
Hypoxic-Ischemic Injury.
Michael V. Johnston, Akira Ishida, Wako Nakajima, William
Trescher.
Chapter 4. Inflammation and Neonatal Brain Injury.
John D.E. Barks, Faye S. Silverstein.
Chapter 5. Glucose, Acidosis, and the Developing Brain.
Robert C. Vannucci, Susan J. Vannucci.
Chapter 6. Energy Consequences of Cerebral Hypoxia-Ischemia.
John S. Wyatt.
Chapter 7. Apoptosis and Necrosis in Perinatal Brain Injury.
Huseyin Mehmet, A. David Edwards.
Chapter 8. Effects of Nitric Oxide on Neuronal and
Cerebrovascular Function.
Donna M. Ferriero, Stephen Ashwal.
Chapter 9. Free Radical-Mediated Processes.
Ola Didrik Saugstad.
.
Part III. Clinical Implications.
Chapter 10. Antepartum Hypoxemia and the Developing Fetus.
Donald M. Peebles, Mark A. Hanson.
Chapter 11. Intrapartum Hypoxic-Ischemic Brain Injury.
Jenny A. Westgate, Laura Bennet, Alistair J. Gunn.
Chapter 12. Clinical Management of the Asphyxiated Newborn.
Malcolm Levene, Sunil K. Sinha.
Chapter 13. Neuroimaging of Hypoxic-Ischemic Encephalopathy.
Mary Rutherford.
Chapter 14. Thermal Influence on the Asphyxiated Newborn.
Marianne Thoresen.
.
Part IV Medico-Legal Aspects.
Chapter 15. Medico-Legal Implications of Hypoxic-Ischemic Brain
Injury.
Steven M. Donn, Malcolm L. Chiswick, Paula Whittell, Susan
Anderson.
Sunil Sinha is the editor of Birth Asphyxia and the Brain: Basic Science and Clinical Implications, published by Wiley.
