Cell Injury
Mechanisms, Responses, and Therapeutics, Volume 1066
Annals of the New York Academy of Sciences
When cells are damaged, as often occurs during trauma and metabolic
stress, a highly evolved cell healing process follows that was
designed to enhance cell survival or remove irreparably injured
cells. Following injury, cells attempt to seal breaks in their
membranes, chaperone removal or refolding of altered proteins,
repair damaged DNA, or if necessary commit to programmed cell
death.
When cell injury is too extensive to permit reparative
responses, acute cellular necrosis or apoptosis can result.
Understanding injury at the subcellular organelle and molecular
levels is essential for development of new therapeutic strategies
and for optimal management of injured victims.
In this volume, various modes of injury that can occur are
described, as well as the basic molecular healing responses and
pathways of metabolic survival or death. The approach taken here is
to look at these processes at the cellular and subcellular levels,
rather than at the tissue level, and this volume will be a valuable
resource to anyone interested in wound healing, biological stress
responses, molecular chaperones, radiobiology, biomechanics, and
biomedical engineering, as well as trauma and critical care
medicine.
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Introduction: Raphael C. Lee, Florin Despa, and Kimm J.
Hamann.
.
Part I: Cell Structure and Integrity:.
1. Biological Water: Its Vital Role in Macromolecular Structure
and Function: Florin Despa.
2. Thermal Stability of Proteins: John C. Bischof and Xiaoming
He.
3. The Physics of the Interactions Governing Folding and
Association of Proteins: Weihua Guo, Joan-Emma Shea, and R Stephen
Berry.
4. Molecular Crowding Effects on Protein Stability: Florin
Despa, Dennis P. Orgill, and Raphael C. Lee.
Part II: Modes of Cell Injury:.
5. Mechanical Cell Injury: Kenneth A. Barbee.
6. Cell Injury by Electric Forces: Raphael C. Lee.
7. Electroconformational Denaturation of Membrane Proteins: Wei
Chen.
8. Heat Injury to Cells in Perfused Systems: Dennis P. Orgill,
Stacy A. Porter, and Helena O. Taylor.
9. Cryo-Injury and Biopreservation: Alex Fowler and Mehmet
Toner.
10. Oxidative Reactive Species in Cell Injury: Mechanisms in
Diabetes Mellitus and Therapeutic Approaches: Leonid E. Fridlyand
and Louis H. Philipson.
Part III: Cellular Responses to Injury:.
11. The Mechanisms of Cell Membrane Repair: A Tutorial Guide to
Key Experiments: Richard A. Steinhardt.
12. The Role of Ca2+ in Muscle Cell Damage: Hanne Gissel.
13. Protein Denaturation and Aggregation: Cellular Responses to
Denatured and Aggregated Proteins: Stephen C. Meredith.
14. Thermally Induced Injury and Heat-Shock Protein Expression
in Cells and Tissues: Marissa Nichole Rylander, Yusheng Feng, Jon
Bass, and Kenneth R. Diller.
15. Cellular Response to DNA Damage: Johnny Kao, Barry S.
Rosenstein, Sheila Peters, Michael T. Milano, and Stephen J.
Kron.
16. Autophagy: Ameeta Kelekar.
17. Magnetic Resonance Imaging of Changes in Muscle Tissues
after Membrane Trauma: Hanne Gissel, Florin Despa, John Collins,
Devkumar Mustafi, Katherine Rojahn, Greg Karczmar, and Raphael
Lee.
Part IV: Therapeutics for Cell Injury:.
18. Na+-K+ Pump Stimulation Improves Contractility in Damaged
Muscle Fibers: Torben Clausen.
19. Multimodal Strategies for Resuscitating Injured Cells:
Jayant Agarwal, Alexandra Walsh, and Raphael C. Lee.
20. Membrane Sealing by Polymers: Stacey A. Maskarinec, Guohui
Wu, and Ka Yee C. Lee.
21. A Surfactant Copolymer Facilitates Functional Recovery of
Heat-Denatured Lysozyme: Alexandra M. Walsh, Devkumar Mustafi,
Marvin W. Makinen, and Raphael C. Lee.
Index of Contributors
