Redox Signaling and Regulation in Biology and Medicine
1. Edition April 2009
XXXIII, 481 Pages, Hardcover
67 Pictures (7 Colored Figures)
The perfect guide to this fascinating field for students and junior researchers integrates the biochemistry, cell biology and medical implications of intracellular redox processes in a readily accessible manner.
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This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way.
Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
Biological Systems Relevant for Redox Signaling and Control
Cellular Generation of Oxidants: Relation to Oxidative Stress
The Chemical Basis of Biological Redox Control
Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins
Hydrogen Peroxide and Cysteine Protein Signaling Pathways
Protein Tyrosine Phosphatases as Mediators of Redox Signaling
Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a
Redox-Controlled Transcription Factors and Gene Expression
Nitric Oxide Regulation in Redox Signaling
Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature?
Aspects of Nox/Duox Signaling
Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling
Oxidative Stress and Apoptosis
Redox Regulation of Apoptosis in Immune Cells
Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System
Free Radicals and Mammalian Aging
Paul Winyard is Professor of Experimental Medicine at Peninsula College of Medicine and Dentistry, Exeter, UK (since 2002). He previously held a Chair in Experimental Medicine at St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, and was a Visiting Professor at the University of California, San Francisco (2000-2001). Paul's research interests centre on the role of oxidative/nitrosative stress in human chronic inflammatory diseases such as rheumatoid arthritis. In particular, he has focused on the development of novel therapeutic strategies and free radical assays, and the translation of these developments into preclinical and early-phase clinical studies.