Medical Biostatistics for Complex Diseases
Quantitative and Network Biology
1. Edition April 2010
XXVIII, 384 Pages, Hardcover
88 Pictures (42 Colored Figures)
36 tables
Practical Approach Book
Short Description
This practical approach gives a comprehensive overview of cutting-edge methods for the analysis of high-throughput data generated through screening for complex diseases like cancer and cardiovascular diseases.
- Out of print -
Further versions
A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.
GENERAL BIOLOGICAL AND STATISTICAL BASICS
The biology of MYC in health and disease: a high altitude view (Turner, Bird and Refaeli)
Cancer Stem Cells - Finding and Hitting the Roots of Cancer (Buss and Ho)
Multiple Testing Methods (Farcomeni)
STATISTICAL AND COMPUTATIONAL ANALYSIS METHODS
Making Mountains Out of Molehills: Moving from Single Gene to Pathway Based Models of Colon Cancer Progression (Edelman, Garman, Potti, Mukherjee)
Gene-Set Expression Analysis: Challenges and Tools (Oron)
Hotelling's T-2 multivariate profiling for detecting differential expression in microarrays (Lu, Liu, Deng)
Interpreting differential coexpression of gene sets (Ju Han Kim, Sung Bum Cho, Jihun Kim)
Multivariate analysis of microarray data: Application of MANOVA (Hwang and Park)
Testing Significance of a Class of Genes (Chen and Tsai)
Differential dependency network analysis to identify topological changes in biological networks (Zhang, Li, Clarke, Hilakivi-Clarke and Wang)
An Introduction to Time-Varying Connectivity Estimation for Gene Regulatory Networks (Fujita, Sato, Almeida Demasi, Miyano, Cleide Sogayar, and Ferreira)
A systems biology approach to construct a cancer-perturbed protein-protein interaction network for apoptosis by means of microarray and database mining (Chu and Chen)
NN, title not confirmed (Fishel, Ruppin)
Kernel Classification Methods for Cancer Microarray Data (Kato and Fujibuchi)
Predicting Cancer Survival Using Expression Patterns (Reddy, Kronek, Brannon, Seiler, Ganesan, Rathmell, Bhanot)
Integration of microarray data sets (Kim and Rha)
Model Averaging For Biological Networks With Prior Information (Mukherjeea, Speed and Hill)
Matthias Dehmer studied mathematics at the University of Siegen, Germany and received his PhD in computer science from the Darmstadt University of Technology. Following this, he was a research fellow at the Vienna Bio Center, Austria, and at the Vienna University of Technology. He is currently an associate professor at UMIT - The Health and Life Sciences University in Hall in Tirol, Austria. His research interests are in bioinformatics, systems biology, complex networks, statistics and information theory. In particular, Matthias Dehmer is working on machine learning-based methods to design new data analysis methods for solving problems in computational and systems biology.
