Novel Therapeutic Proteins
Selected Case Studies
1. Edition November 2000
XXIV, 358 Pages, Hardcover
56 Pictures (4 Colored Figures)
32 tables
Handbook/Reference Book
Short Description
This book respresents a summary and analysis of 15 of the most important proteins that are currently used therapeutically. Each chapter covers all aspects of the respective protein with a clear focus on clinical data. Comprehensive cases studies are used liberally to illustrate key concepts and demonstrate effective development of therapeutics.
- Out of print -
Further versions
This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology.
Foreword written by Jürgen Drews.
Preface (Klaus Dembowsky and Peter Stadler)
INTRODUCTION AND OVERVIEW
Medical Applications of Recombinant Proteins in Humans
Gayle Delmonte Wetzel
RECOMBINANT HORMONES
Clinical Applications of Recombinant Human Erythropoietin (Dimitrios Spentzos and Arthur J. Sytkowski)
Human Recombinant Growth Hormone (Carmen Ariznavarreta Ruiz and Jesús A.F. Tresguerres)
Human Recombinant Follicle Stimulating Hormone (Follitropin-a) (José A. Peinado, Colin M. Howles, and Jesús A.F. Tresguerres)
RECOMBINANT CYTOKINES AND THEIR RECEPTORS
Granulocyte Colony Stimulating Factor (G-CSF) (Karl Welte)
Interferon b-1b in Multiple Sclerosis (Bernd Aufdembrinke, Reinhard Horowski, and Joachim-Friedrich Kapp)
TNF-a -Receptors as Recombinant Proteins in Treatment of Rheumatoid Arthritis (Hanns-Martin Lorenz and Joachim R. Kalden)
RECOMBINANT ENZYMES, ENZYME ACTIVATORS AND INHIBITORS
Improvement of Principles of Nature: t-PA (Rolf G. Werner and Gerhard Heusel)
The Clinical Development of Recombinant Coagulation Factor VIII (KogenateÒ) for the Treatment of Hemophilia A (Peter J. Larson)
Aprotinin, Recombinant Aprotinin and Recombinant Aprotinin Mutants (Klaus Dembowsky and Werner Schroeder)
RECOMBINANT VACCINES
Recombinant Hepatitis B Vaccines -- Characterization of the Viral Disease and Vaccine Production in the Methylotrophic Yeast, Hansenula polymorpha (Stephan Schaefer, Michael Piontek, Sang-Jeom Ahn, Adam Papendieck, Zbigniew A. Janowicz and Gerd Gellissen)
MONOCLONAL ANTIBODIES
Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (Mark Sopwith)
Antibody Therapy for Sepsis: Some Lessons Learned (Steven M. Opal)
An Engineered Human Antibody for Chronic Therapy: CDP571 (Mark Sopwith and Sue Stephens)
The Evolution of ReoPro(r) Clinical Development (Catherine F. Farrell, Elliot S. Barnathan and Harlan F. Weisman)
Index
