Signal Transduction and Human Disease
1. Edition June 2003
488 Pages, Hardcover
Wiley & Sons Ltd
Short Description
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Contributors.
Introduction.
1. Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals (J. Hill, et al.).
2. NF-κB: A Key Signaling Pathway in Asthma (S. Levine).
3. Molecular Mechanisms of Cancer (A. Sodhi, et al.).
4. Apoptotic Pathways in Cancer Progression and Treatment (J. Chandra & S. Kaufmann).
5. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes (D. Le Roith, et al.).
6. Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases (W. Simonds).
7. Bacterial Regulation of the Cytoskeleton (J. Peck, et al.).
8. Bacterial Toxins and Diarrhea (W. Patton, et al.).
9. Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways (R. Visconti, et al.).
10. Mast Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies (M. Beaven & T. Hundley).
11. Rheumatology and Signal Transduction (K. Hull & D. Kastner).
12. Molecular Mechanisms of Neurodegenerative Disorders (B. Wolozin).
13. Neurotrophic Signaling in Mood Disorders (J. Du, et al.).
14. Inhibiting Signaling Pathways Through Rational Drug Design (J. Topper & N. Giese).
Index.
Cell, January 9, 2004
