Multi-Step Enzyme Catalysis

Biotransformations and Chemoenzymatic Synthesis

Garcia-Junceda, Eduardo (Editor)

1. Edition September 2008
XV, 241 Pages, Hardcover
218 Pictures (12 Colored Figures)
5 tables
Monograph

ISBN: 978-3-527-31921-3

Wiley-VCH, Weinheim

Wiley Online Library Content Sample Chapter Index

Short Description

The first comprehensive coverage of this fascinating field opens the door to reactions hitherto unknown, making this monograph of great interest to the pharmaceutical and fine chemical industry.

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The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.

Multi-Enzyme Synthesis of Glycoconjugates
Multimodular Synthases as Tools of the Synthetic Chemist
Modifying the Glycosilation Pattern in Microorganisms by Combinatorial Biosynthesis
Chemoenzymatic Routes to Enantiomerically Pure Amines and Aminoacids
Asymmetric Transformations by Couples Enzymes and Metal Catalysis
Engineering Novel Biosynthetic Pathways to Produce New Chemical Compounds
Biocatalysis and Chemical Catalysis for the Synthesis of Intermediates of Pharmaceutical Interest
Oxidizing Enzymes into Multi-Enzyme Biotransformation Processes
The Role of Host-Intrinsic Enzyme Activities in Recombinant Whole-Cells Catalyzed Processes
Microbial Production of DNA Building Blocks
Enzyme Initiation of Asymmetric Cascade-Reactions
The System of Biotransformations Approach for Multi-Step Processes
Chemoenzymatic Synthesis of Homogeneous Glycoprotein
Aldolases Catalyzed C-C Bond Formation in the Core of Multi-Step Processes

Eduardo García-Junceda received his PhD at the Plant Physiology Department at the University of Madrid. He joined Chi-Huey Wong's Group at The Scripps Research Institute (La Jolla, California) as postdoctoral fellow. After his return to Spain in 1995, he was appointed Research Staff Member in the Institute of Organic Chemistry of CSIC in 1997. His research interests concentrate on molecular biology applied to organic synthesis and enzyme catalysis.

E. Garcia-Junceda, Departamento de Química Orgánica Biológica, CSIC, Madrid, Spain