Nutritional Genomics
Discovering the Path to Personalized Nutrition
1. Edition June 2006
496 Pages, Hardcover
Practical Approach Book
Short Description
Nutritional Genomics provides an integrated and up-to-date overview of the fundamental principles and scientific methodologies that serve as the foundation for nutrigenomics. World-renowned experts in the field of nutrigenomics have contributed their latest breakthroughs and insights in their particular areas of expertise. While each chapter can be used as a complete, stand-alone unit, they are all organized so that the chapters build on each other, leading the reader smoothly from basic principles to more complex scientific findings and experimental designs. Moreover, scientifically focused chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.
The definitive guide to the basic principles and latest advances in Nutritional Genomics
Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer.
Topics covered include:
* Nutrients and gene expression
* The role of metabolomics in individualized health
* Molecular mechanisms of longevity regulation and calorie restriction
* Green tea polyphenols and soy peptides in cancer prevention
* Maternal nutrition and fetal gene expression
* Genetic susceptibility to heterocyclic amines from cooked foods
* Bioinformatics and biocomputation in nutrigenomics
* The pursuit of optimal diets
Written by an all-star team of experts from around the globe, this volume provides an integrated overview of the cutting-edge field of nutritional genomics. The authors and editors lead an in-depth discussion of the fundamental principles and scientific methodologies that serve as the foundation for nutritional genomics and explore important recent advances in an array of related disciplines. Each self-contained chapter builds upon its predecessor, leading the reader seamlessly from basic principles to more complex scientific findings and experimental designs. Scientific chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.
Foreword.
Preface.
Acknowledgments.
1. An Introduction and Overview of Nutritional Genomics: Application to Type 2 Diabetes and International Nutrigenomics (Jim Kaput).
2. The Pursuit of Optimal Diets: A Progress Report (Walter C. Willett).
3. Gene - Environment Interactions: Defining the Playfield (Jose M. Ordovas and Dolores Corella).
4. Metabolomics: Bringing Nutrigenomics to Practice in Individualized Health Asssessment (J. Bruce German, Cora J. Dillard, S. Luke Hillyard, Matthew C. Lange, Jennifer T. Smilowitz, Robert E. Ward, and Angela M. Zivkovic).
5. Genetic and molecular buffering of phenotypes (John L. Hartman, IV).
6. Gene - Gene Epistasis and Gene - Environment Interactions Influence Diabetes and Obesity (Sally Chiu, Adam L. Diament, Janis S. Fisler, and Craig H. Warden).
7. Nutrients and Gene Expression (Gertrud U. Schuster).
8. Green Tea Polyphenols and Cancer Prevention (Shangqin Guo and Gail Sonenshein).
9. Molecular Mechanisms of Longevity Regulation and Calorie Restriction (Su - Ju Lin).
10. Maternal Nutrition: Nutrients and Control of Expression (Craig A. Cooney).
11. Nutrient - Gene Interactions Involving Soy Peptide and Chemopreventive Genes in Prostate Epithelial Cells (Mark Jesus M. Magbanua, Kevin Dawson, Liping Huang, Wasyl Malyj, Jeff Gregg, Alfredo Galvez, and Raymond L. Rodriguez).
12. Enzymes Lose Binding Affinity (increase Km) for Coenzymes and Substrates with Age: A Strategy for Remediation (Bruce N. Ames, Jung H. Suh, and Jiankang Liu).
13. Dietary and Genetic Effects on Atherogenic Dyslipidemia (Ronald M. Krauss, MD, and Patty W. Siri, PhD, MS).
14. Genistein And Polythenols in the Study of Cancer Prevention: Chemistry, Biology, Statistics and Experimental Design (Stephen Barnes, David B. Allison, Grier P. Page, Mark Carpenter, Gary L. Gadbury, Sreelatha Meleth, Pamela Horn-Ross, Helen Kim, Coral A. Lamartinere, and Clinton J. Grubbs).
15. Susceptibility to Exposure to Heterocyclic Amines from Cooked Food: Role of UDP-glucuronosyltransferases (Michael A. Malfatti and James S. Felton).
16. The Informatics and Bioinformatics Infrastructure of a Nutrigenomics Biobank (Warren A. Kibbe).
17. Biocomputation and the Analysis of Complex Datasets in Nutritional Genomics (Kevin Dawson, Raymond L. Rodriguez, Wayne Chris Hawkes, and Wasyl Malyj).
18. Cultural Humility: A Contribution to Health Professional Education in Nutrigenomics (Melanie Tervalon).
19. Nutrients and Norms: Ethical Issues in Nutritional Genomics (David Castle, Cheryl Cline, Abdallah S. Daar, Charoula Tsamis, and Peter A. Singer).
Glossary.
Index.
"...academic libraries with strong medical and genetic departments would do well to purchase this text." (E-STREAMS, September 2007)
"...there is much valuable information here for the interested reader. I would recommend the book to students and colleagues..." (Doody's Health Services)
Raymond L. Rodriguez, PhD, is Professor of Molecular and Cellular Biology and Director of the Centerof Excellence in Nutritional Genomics at the University of California, Davis.
