Spiro Compounds
Synthesis and Applications
1. Edition March 2022
464 Pages, Hardcover
Wiley & Sons Ltd
Short Description
This comprehensive book captures the advances that have been made in the synthesis of spiro compounds, focusing on the enantioselective methodologies. The book has a special focus in the mechanism of the reactions that lead to the synthesis of spiro compounds. The introductory chapter reviews the history, significance and unique properties of spiro compounds. One chapter focuses on the applications of spiro compounds in organic chemistry and other fields like biology and drug discovery and another chapter describes the most important syntheses of natural products bearing a spiro ring.
Further versions
SPIRO COMPOUNDS
A comprehensive treatment of the latest research in, and applications of, spiro compounds
Spiro Compounds: Synthesis and Applications combines discussions of the latest advances in spiro compound research with the most cutting-edge, real-world applications of that knowledge. This book provides in-depth coverage of the history, significance, properties, synthetic methods, and applications of spiro compounds. As interest in spiro compounds grows due to their unique conformational features and their structural implications on biological systems, Spiro Compounds delivers fulsome treatments of advances in spiro compound synthesis (including stereoselective synthesis) methodologies.
With a special focus on the mechanisms of the reactions that lead to the synthesis of spiro compounds, chapters in the book cover topics such as:
* The history, significance, and unique properties of spiro compounds
* The most important methodologies for their synthesis
* The applications of spiro compounds in organic chemistry, biology, drug discovery
* The most important syntheses of natural products bearing a spiro ring
Perfect for academic and industrial chemists, this comprehensive discussion of spirocycles is an indispensable resource for those practicing in the field.
Table of Contents
List of Contributors
Preface
CHAPTER 1. Spiro Compounds: A Brief Story
CHAPTER 2. Selected Applications of Spirocycles in Medicinal Chemistry
CHAPTER 3. Recent Advances in the Asymmetric Synthesis of Spiro Compounds through Cycloadditions
CHAPTER 4. Design and Synthesis of Spirocycles via Olefin Metathesis
CHAPTER 5. Spirooxindoles, synthesis via organocatalytic processes
CHAPTER 6. Spirooxindole synthesis by organometallic processes
CHAPTER 7. Enantioselective synthesis of spiro heterocycles
CHAPTER 8. Enantioselective synthesis of all carbon spiro compounds
CHAPTER 9. Transition-Metal-Catalyzed Dearomative Spiroannulation Reactions
CHAPTER 10. Carbocyclic Spiro Compounds Occupying Higher Dimensions: Benzoannelated [5.5.5.5]Fenestranes and Beyond
CHAPTER 11. The synthesis of natural products containing spirocycles
Index
